Tandem chimeric antigen receptor (CAR) T cells targeting EGFRvIII and IL-13Rα2 are effective against heterogeneous glioblastoma

BACKGROUND: Chimeric antigen receptor (CAR) T cells have achieved remarkable responses in patients with hematological malignancies; however, the potential of this therapeutic platform for solid tumors like glioblastoma (GBM) has been limited, due in large part to the targeting of single antigens in...

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Detalles Bibliográficos
Autores principales: Schmidts, Andrea, Srivastava, Ambike A, Ramapriyan, Rishab, Bailey, Stefanie R, Bouffard, Amanda A, Cahill, Daniel P, Carter, Bob S, Curry, William T, Dunn, Gavin P, Frigault, Matthew J, Gerstner, Elizabeth R, Ghannam, Jack Y, Kann, Michael C, Larson, Rebecca C, Leick, Mark B, Nahed, Brian V, Richardson, Leland G, Scarfò, Irene, Sun, Jing, Wakimoto, Hiroaki, Maus, Marcela V, Choi, Bryan D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896600/
https://www.ncbi.nlm.nih.gov/pubmed/36751672
http://dx.doi.org/10.1093/noajnl/vdac185

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