ShrinkCRISPR: a flexible method for differential fitness analysis of CRISPR-Cas9 screen data

BACKGROUND: CRISPR screens provide large-scale assessment of cellular gene functions. Pooled libraries typically consist of several single guide RNAs (sgRNAs) per gene, for a large number of genes, which are transduced in such a way that every cell receives at most one sgRNA, resulting in the disrup...

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Detalles Bibliográficos
Autores principales: Tissier, Renaud L. M., Schie, Janne J. M. van, Wolthuis, Rob M. F., Lange, Job de, Menezes, Renée de
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896759/
https://www.ncbi.nlm.nih.gov/pubmed/36732720
http://dx.doi.org/10.1186/s12859-023-05142-1

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