The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling

BACKGROUND: Patients suffering from chronic pain often also exhibit depression symptoms. Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory cytokines. However, whether inhibiting sEH signaling is beneficial for the comorbidity of pain and depression is unknown. METH...

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Detalles Bibliográficos
Autores principales: Luo, Ailin, Wu, Zifeng, Li, Shan, McReynolds, Cindy B., Wang, Di, Liu, Hanyu, Huang, Chaoli, He, Teng, Zhang, Xinying, Wang, Yuanyuan, Liu, Cunming, Hammock, Bruce D., Hashimoto, Kenji, Yang, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896784/
https://www.ncbi.nlm.nih.gov/pubmed/36732752
http://dx.doi.org/10.1186/s12967-023-03917-x

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