Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms

BACKGROUND: C3G is a guanine nucleotide exchange factor (GEF) that activates Rap1 to promote cell adhesion. Resting C3G is autoinhibited and the GEF activity is released by stimuli that signal through tyrosine kinases. C3G is activated by tyrosine phosphorylation and interaction with Crk adaptor pro...

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Detalles Bibliográficos
Autores principales: Rodríguez-Blázquez, Antonio, Carabias, Arturo, Morán-Vaquero, Alba, de Cima, Sergio, Luque-Ortega, Juan R., Alfonso, Carlos, Schuck, Peter, Manso, José Antonio, Macedo-Ribeiro, Sandra, Guerrero, Carmen, de Pereda, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896810/
https://www.ncbi.nlm.nih.gov/pubmed/36737758
http://dx.doi.org/10.1186/s12964-023-01042-2

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