Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators

Kv3 ion-channels constitute a class of functionally distinct voltage-gated ion channels characterized by their ability to fire at a high frequency. Several disease relevant mutants, together with biological data, suggest the importance of this class of ion channels as drug targets for CNS disorders,...

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Detalles Bibliográficos
Autores principales: Botte, Mathieu, Huber, Sophie, Bucher, Denis, Klint, Julie K, Rodríguez, David, Tagmose, Lena, Chami, Mohamed, Cheng, Robert, Hennig, Michael, Abdul Rahman, Wassim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896932/
https://www.ncbi.nlm.nih.gov/pubmed/36741467
http://dx.doi.org/10.1093/pnasnexus/pgac083

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