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Solvent-driven biotoxin into nano-units as a versatile and sensitive SERS strategy

In recent years, marine biotoxins have posed a great threat to fishermen, human security and military prevention and control due to their diverse, complex, toxic and widespread nature, and the development of rapid and sensitive methods is essential. Surface-enhanced Raman spectroscopy (SERS) is a pr...

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Detalles Bibliográficos
Autores principales: Cheng, Yizhuang, Qin, Miao, Li, Pan, Yang, Liangbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897048/
https://www.ncbi.nlm.nih.gov/pubmed/36760288
http://dx.doi.org/10.1039/d2ra07216e
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author Cheng, Yizhuang
Qin, Miao
Li, Pan
Yang, Liangbao
author_facet Cheng, Yizhuang
Qin, Miao
Li, Pan
Yang, Liangbao
author_sort Cheng, Yizhuang
collection PubMed
description In recent years, marine biotoxins have posed a great threat to fishermen, human security and military prevention and control due to their diverse, complex, toxic and widespread nature, and the development of rapid and sensitive methods is essential. Surface-enhanced Raman spectroscopy (SERS) is a promising technique for the rapid and sensitive in situ detection of marine biotoxins due to its advantages of rapid, high sensitivity, and fingerprinting information. However, the complex structure of toxin molecules, small Raman scattering cross-section and low affinity to conventional substrates make it difficult to achieve direct and sensitive SERS detection. Here, we generate a large number of active hotspot structures by constructing monolayer nanoparticle films with high density hotspots, which have good target molecules that can actively access the hotspot structures using nanocapillaries. In addition, the efficient and stable signal can be achieved during dynamic detection, increasing the practicality and operability of the method. This versatile SERS method achieves highly sensitive detection of marine biotoxins GTX and NOD, providing good prospects for convenient, rapid and sensitive SERS detection of marine biotoxins.
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spelling pubmed-98970482023-02-08 Solvent-driven biotoxin into nano-units as a versatile and sensitive SERS strategy Cheng, Yizhuang Qin, Miao Li, Pan Yang, Liangbao RSC Adv Chemistry In recent years, marine biotoxins have posed a great threat to fishermen, human security and military prevention and control due to their diverse, complex, toxic and widespread nature, and the development of rapid and sensitive methods is essential. Surface-enhanced Raman spectroscopy (SERS) is a promising technique for the rapid and sensitive in situ detection of marine biotoxins due to its advantages of rapid, high sensitivity, and fingerprinting information. However, the complex structure of toxin molecules, small Raman scattering cross-section and low affinity to conventional substrates make it difficult to achieve direct and sensitive SERS detection. Here, we generate a large number of active hotspot structures by constructing monolayer nanoparticle films with high density hotspots, which have good target molecules that can actively access the hotspot structures using nanocapillaries. In addition, the efficient and stable signal can be achieved during dynamic detection, increasing the practicality and operability of the method. This versatile SERS method achieves highly sensitive detection of marine biotoxins GTX and NOD, providing good prospects for convenient, rapid and sensitive SERS detection of marine biotoxins. The Royal Society of Chemistry 2023-02-03 /pmc/articles/PMC9897048/ /pubmed/36760288 http://dx.doi.org/10.1039/d2ra07216e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Cheng, Yizhuang
Qin, Miao
Li, Pan
Yang, Liangbao
Solvent-driven biotoxin into nano-units as a versatile and sensitive SERS strategy
title Solvent-driven biotoxin into nano-units as a versatile and sensitive SERS strategy
title_full Solvent-driven biotoxin into nano-units as a versatile and sensitive SERS strategy
title_fullStr Solvent-driven biotoxin into nano-units as a versatile and sensitive SERS strategy
title_full_unstemmed Solvent-driven biotoxin into nano-units as a versatile and sensitive SERS strategy
title_short Solvent-driven biotoxin into nano-units as a versatile and sensitive SERS strategy
title_sort solvent-driven biotoxin into nano-units as a versatile and sensitive sers strategy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897048/
https://www.ncbi.nlm.nih.gov/pubmed/36760288
http://dx.doi.org/10.1039/d2ra07216e
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