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Magic bullets, magic shields, and antimicrobials in between
There are only two classes of small-molecule drugs for infectious disease: pathogen-directed antimicrobials and host-directed immunomodulators. The former includes antibiotics and antivirals while the latter comprises corticosteroids such as dexamethasone. Here I inaugurate a third class, immunomodu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author. Published by Elsevier B.V. on behalf of Shandong University.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897060/ http://dx.doi.org/10.1016/j.pscia.2022.100002 |
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author | Prathapan, Praveen |
author_facet | Prathapan, Praveen |
author_sort | Prathapan, Praveen |
collection | PubMed |
description | There are only two classes of small-molecule drugs for infectious disease: pathogen-directed antimicrobials and host-directed immunomodulators. The former includes antibiotics and antivirals while the latter comprises corticosteroids such as dexamethasone. Here I inaugurate a third class, immunomodulatory antimicrobials (IAs), which considers small-molecule drugs harbouring both pathogen-directed and host-directed pharmacology. I review seven types of IAs, and argue that their high repositionability and network pharmacological ability to counter multiple pathogen types render them more applicable to pandemic-preparedness research than antivirals. |
format | Online Article Text |
id | pubmed-9897060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Author. Published by Elsevier B.V. on behalf of Shandong University. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98970602023-02-06 Magic bullets, magic shields, and antimicrobials in between Prathapan, Praveen Pharmaceutical Science Advances Article There are only two classes of small-molecule drugs for infectious disease: pathogen-directed antimicrobials and host-directed immunomodulators. The former includes antibiotics and antivirals while the latter comprises corticosteroids such as dexamethasone. Here I inaugurate a third class, immunomodulatory antimicrobials (IAs), which considers small-molecule drugs harbouring both pathogen-directed and host-directed pharmacology. I review seven types of IAs, and argue that their high repositionability and network pharmacological ability to counter multiple pathogen types render them more applicable to pandemic-preparedness research than antivirals. The Author. Published by Elsevier B.V. on behalf of Shandong University. 2023-03 2022-12-16 /pmc/articles/PMC9897060/ http://dx.doi.org/10.1016/j.pscia.2022.100002 Text en © 2022 The Author Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Prathapan, Praveen Magic bullets, magic shields, and antimicrobials in between |
title | Magic bullets, magic shields, and antimicrobials in between |
title_full | Magic bullets, magic shields, and antimicrobials in between |
title_fullStr | Magic bullets, magic shields, and antimicrobials in between |
title_full_unstemmed | Magic bullets, magic shields, and antimicrobials in between |
title_short | Magic bullets, magic shields, and antimicrobials in between |
title_sort | magic bullets, magic shields, and antimicrobials in between |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897060/ http://dx.doi.org/10.1016/j.pscia.2022.100002 |
work_keys_str_mv | AT prathapanpraveen magicbulletsmagicshieldsandantimicrobialsinbetween |