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Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model
Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO(2)) into biodegradable carrier f...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897158/ https://www.ncbi.nlm.nih.gov/pubmed/36776789 http://dx.doi.org/10.1007/s10570-023-05070-6 |
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author | Wang, Yanan Zhao, Hanyu Huang, Lijie Chen, Guangxue Wei, Zhehao Mo, Qi Li, Yishan Wang, Xiyue Huang, Chongxing Chen, Qifeng |
author_facet | Wang, Yanan Zhao, Hanyu Huang, Lijie Chen, Guangxue Wei, Zhehao Mo, Qi Li, Yishan Wang, Xiyue Huang, Chongxing Chen, Qifeng |
author_sort | Wang, Yanan |
collection | PubMed |
description | Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO(2)) into biodegradable carrier for its good disinfection performance and high safety factors has attracted significantattention. Therefore, in this study, we used ClO(2) as a model drug, and a sustained-ClO(2)-gas-release gel was developed from degradable materials, such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and β-cyclodextrin (βCD), through a simple and benign crosslinking strategy. Notably, the gel had sustained-release property in a wide temperature range of 4–35 ℃ and released ClO(2) gas effectively for more than 30 days. Furthermore, a loss factor was proposed based on the incomplete release of the drug in the sustained release process to a chieve a good fit with the gas diffusion process. A new diffusion model was designed based on the Korsmeyer–Peppas model, and an excellent fit was obtained. This sustained-ClO(2)-gas-release gel provides theoretical and technical guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained release model of skeleton-soluble hydrogels. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10570-023-05070-6. |
format | Online Article Text |
id | pubmed-9897158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-98971582023-02-06 Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model Wang, Yanan Zhao, Hanyu Huang, Lijie Chen, Guangxue Wei, Zhehao Mo, Qi Li, Yishan Wang, Xiyue Huang, Chongxing Chen, Qifeng Cellulose (Lond) Original Research Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO(2)) into biodegradable carrier for its good disinfection performance and high safety factors has attracted significantattention. Therefore, in this study, we used ClO(2) as a model drug, and a sustained-ClO(2)-gas-release gel was developed from degradable materials, such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and β-cyclodextrin (βCD), through a simple and benign crosslinking strategy. Notably, the gel had sustained-release property in a wide temperature range of 4–35 ℃ and released ClO(2) gas effectively for more than 30 days. Furthermore, a loss factor was proposed based on the incomplete release of the drug in the sustained release process to a chieve a good fit with the gas diffusion process. A new diffusion model was designed based on the Korsmeyer–Peppas model, and an excellent fit was obtained. This sustained-ClO(2)-gas-release gel provides theoretical and technical guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained release model of skeleton-soluble hydrogels. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10570-023-05070-6. Springer Netherlands 2023-02-03 2023 /pmc/articles/PMC9897158/ /pubmed/36776789 http://dx.doi.org/10.1007/s10570-023-05070-6 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Research Wang, Yanan Zhao, Hanyu Huang, Lijie Chen, Guangxue Wei, Zhehao Mo, Qi Li, Yishan Wang, Xiyue Huang, Chongxing Chen, Qifeng Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model |
title | Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model |
title_full | Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model |
title_fullStr | Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model |
title_full_unstemmed | Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model |
title_short | Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model |
title_sort | development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897158/ https://www.ncbi.nlm.nih.gov/pubmed/36776789 http://dx.doi.org/10.1007/s10570-023-05070-6 |
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