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Focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance–guided high-intensity focused ultrasound targeting

Magnetic resonance–guided high-intensity focused ultrasound thalamotomy is a Food and Drug Administration–approved treatment for essential tremor. The target, the ventral intermediate nucleus of the thalamus, is not visualized on standard, anatomic MRI sequences. Several recent reports have used dif...

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Autores principales: Feltrin, Fabricio S, Chopra, Rajiv, Pouratian, Nader, Elkurd, Mazen, El-Nazer, Rasheda, Lanford, Lauren, Dauer, William, Shah, Bhavya R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897190/
https://www.ncbi.nlm.nih.gov/pubmed/36751499
http://dx.doi.org/10.1093/braincomms/fcac273
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author Feltrin, Fabricio S
Chopra, Rajiv
Pouratian, Nader
Elkurd, Mazen
El-Nazer, Rasheda
Lanford, Lauren
Dauer, William
Shah, Bhavya R
author_facet Feltrin, Fabricio S
Chopra, Rajiv
Pouratian, Nader
Elkurd, Mazen
El-Nazer, Rasheda
Lanford, Lauren
Dauer, William
Shah, Bhavya R
author_sort Feltrin, Fabricio S
collection PubMed
description Magnetic resonance–guided high-intensity focused ultrasound thalamotomy is a Food and Drug Administration–approved treatment for essential tremor. The target, the ventral intermediate nucleus of the thalamus, is not visualized on standard, anatomic MRI sequences. Several recent reports have used diffusion tensor imaging to target the dentato-rubro-thalamic-tract. There is considerable variability in fibre tracking algorithms and what fibres are tracked. Targeting discrete white matter tracts with magnetic resonance–guided high-intensity focused ultrasound is an emerging precision medicine technique that has the promise to improve patient outcomes and reduce treatment times. We provide a technical overview and clinical benefits of our novel, easily implemented advanced tractography method: four-tract tractography. Our method is novel because it targets both the decussating and non-decussating dentato-rubro-thalamic-tracts while avoiding the medial lemniscus and corticospinal tracts. Our method utilizes Food and Drug Administration-approved software and is easily implementable into existing workflows. Initial experience using this approach suggests that it improves patient outcomes by reducing the incidence of adverse effects.
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spelling pubmed-98971902023-02-06 Focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance–guided high-intensity focused ultrasound targeting Feltrin, Fabricio S Chopra, Rajiv Pouratian, Nader Elkurd, Mazen El-Nazer, Rasheda Lanford, Lauren Dauer, William Shah, Bhavya R Brain Commun Original Article Magnetic resonance–guided high-intensity focused ultrasound thalamotomy is a Food and Drug Administration–approved treatment for essential tremor. The target, the ventral intermediate nucleus of the thalamus, is not visualized on standard, anatomic MRI sequences. Several recent reports have used diffusion tensor imaging to target the dentato-rubro-thalamic-tract. There is considerable variability in fibre tracking algorithms and what fibres are tracked. Targeting discrete white matter tracts with magnetic resonance–guided high-intensity focused ultrasound is an emerging precision medicine technique that has the promise to improve patient outcomes and reduce treatment times. We provide a technical overview and clinical benefits of our novel, easily implemented advanced tractography method: four-tract tractography. Our method is novel because it targets both the decussating and non-decussating dentato-rubro-thalamic-tracts while avoiding the medial lemniscus and corticospinal tracts. Our method utilizes Food and Drug Administration-approved software and is easily implementable into existing workflows. Initial experience using this approach suggests that it improves patient outcomes by reducing the incidence of adverse effects. Oxford University Press 2022-10-25 /pmc/articles/PMC9897190/ /pubmed/36751499 http://dx.doi.org/10.1093/braincomms/fcac273 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Feltrin, Fabricio S
Chopra, Rajiv
Pouratian, Nader
Elkurd, Mazen
El-Nazer, Rasheda
Lanford, Lauren
Dauer, William
Shah, Bhavya R
Focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance–guided high-intensity focused ultrasound targeting
title Focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance–guided high-intensity focused ultrasound targeting
title_full Focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance–guided high-intensity focused ultrasound targeting
title_fullStr Focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance–guided high-intensity focused ultrasound targeting
title_full_unstemmed Focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance–guided high-intensity focused ultrasound targeting
title_short Focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance–guided high-intensity focused ultrasound targeting
title_sort focused ultrasound using a novel targeting method four-tract tractography for magnetic resonance–guided high-intensity focused ultrasound targeting
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897190/
https://www.ncbi.nlm.nih.gov/pubmed/36751499
http://dx.doi.org/10.1093/braincomms/fcac273
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