Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling

Despite the robust healing capacity of the liver, regenerative failure underlies numerous hepatic diseases, including the JAG1 haploinsufficient disorder, Alagille syndrome (ALGS). Cholestasis due to intrahepatic duct (IHD) paucity resolves in certain ALGS cases but fails in most with no clear mecha...

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Detalles Bibliográficos
Autores principales: Zhao, Chengjian, Matalonga, Jonathan, Lancman, Joseph J., Liu, Lu, Xiao, Chaoxin, Kumar, Shiv, Gates, Keith P., He, Jiaye, Graves, Alyssa, Huisken, Jan, Azuma, Mizuki, Lu, Zhenghao, Chen, Chong, Ding, Bi-Sen, Dong, P. Duc Si
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897440/
https://www.ncbi.nlm.nih.gov/pubmed/36469766
http://dx.doi.org/10.1073/pnas.2201097119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897440/
https://www.ncbi.nlm.nih.gov/pubmed/36469766
http://dx.doi.org/10.1073/pnas.2201097119

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