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The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops

R-loops, or RNA:DNA hybrids, can induce DNA damage, which requires DNA repair factors including breast cancer type 1 susceptibility protein (BRCA1) to restore genomic integrity. To date, several pathogenic mutations have been found within the tandem BRCA1 carboxyl-terminal (BRCT) domains that mediat...

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Detalles Bibliográficos
Autores principales:	Chang, Chou-Wei, Singh, Anup Kumar, Li, Min, Guan, Li, Le, Nhung, Omabe, Kenneth, Liang, Feng, Liu, Yilun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897471/ https://www.ncbi.nlm.nih.gov/pubmed/36490315 http://dx.doi.org/10.1073/pnas.2217542119

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