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SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers

The formation of toxic Amyloid β-peptide (Aβ) oligomers is one of the earliest events in the molecular pathology of Alzheimer’s Disease (AD). These oligomers lead to a variety of downstream effects, including impaired neuronal signaling, neuroinflammation, tau phosphorylation, and neurodegeneration,...

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Detalles Bibliográficos
Autores principales:	Shea, Dylan, Colasurdo, Elizabeth, Smith, Alec, Paschall, Courtnie, Jayadev, Suman, Keene, C. Dirk, Galasko, Douglas, Ko, Andrew, Li, Ge, Peskind, Elaine, Daggett, Valerie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897489/ https://www.ncbi.nlm.nih.gov/pubmed/36490316 http://dx.doi.org/10.1073/pnas.2213157119

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