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Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis
BACKGROUND: Atopic dermatitis is a chronic pruritic inflammatory skin disease commonly occurring in children. The objective of this study is to evaluate the treatment of pediatric atopic dermatitis with biologics, as they have displayed immense promising results in several recent clinical trials on...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897544/ https://www.ncbi.nlm.nih.gov/pubmed/36735725 http://dx.doi.org/10.1371/journal.pone.0271712 |
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author | Cao, Rui Lu, Jiaxing Chen, Zhao |
author_facet | Cao, Rui Lu, Jiaxing Chen, Zhao |
author_sort | Cao, Rui |
collection | PubMed |
description | BACKGROUND: Atopic dermatitis is a chronic pruritic inflammatory skin disease commonly occurring in children. The objective of this study is to evaluate the treatment of pediatric atopic dermatitis with biologics, as they have displayed immense promising results in several recent clinical trials on atopic dermatitis (AD). METHODS: We will conduct an extensive search for RCTs in several databases, including Embase, Cochrane Library, Web of Science, and PubMed, from the inception of the study till 15th May 2022. The primary outcomes will be the proportion of patients with EASI 75/90/100 after 12–16 weeks of treatment. The secondary outcomes will include the Numerical Rating Scale (NRS), Investigator Global Assessment (IGA)0–1, body surface area (BSA), Dermatology Life Quality Index (DLQI) scores, and incidence of adverse reactions. All studies will be screened by two independent researchers. They will assess the risk of bias in the included studies according to the RCTs bias risk evaluation tool in Cochrane System Review Manual 5.1.0. Meta-analysis will be performed using RevMan V.5.3.0 software. RESULTS: The research results will provide a reference for the clinical application of biological agents in pediatric atopic dermatitis. CONCLUSION: We aim to evaluate the efficacy and safety of biologics in pediatric atopic dermatitis cases and provide evidence-based data for easy clinical application. PROSPERO REGISTRATION NUMBER: CRD42022319052 (https://www.crd.york.ac.uk/PROSPERO/#joinuppage). |
format | Online Article Text |
id | pubmed-9897544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-98975442023-02-04 Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis Cao, Rui Lu, Jiaxing Chen, Zhao PLoS One Study Protocol BACKGROUND: Atopic dermatitis is a chronic pruritic inflammatory skin disease commonly occurring in children. The objective of this study is to evaluate the treatment of pediatric atopic dermatitis with biologics, as they have displayed immense promising results in several recent clinical trials on atopic dermatitis (AD). METHODS: We will conduct an extensive search for RCTs in several databases, including Embase, Cochrane Library, Web of Science, and PubMed, from the inception of the study till 15th May 2022. The primary outcomes will be the proportion of patients with EASI 75/90/100 after 12–16 weeks of treatment. The secondary outcomes will include the Numerical Rating Scale (NRS), Investigator Global Assessment (IGA)0–1, body surface area (BSA), Dermatology Life Quality Index (DLQI) scores, and incidence of adverse reactions. All studies will be screened by two independent researchers. They will assess the risk of bias in the included studies according to the RCTs bias risk evaluation tool in Cochrane System Review Manual 5.1.0. Meta-analysis will be performed using RevMan V.5.3.0 software. RESULTS: The research results will provide a reference for the clinical application of biological agents in pediatric atopic dermatitis. CONCLUSION: We aim to evaluate the efficacy and safety of biologics in pediatric atopic dermatitis cases and provide evidence-based data for easy clinical application. PROSPERO REGISTRATION NUMBER: CRD42022319052 (https://www.crd.york.ac.uk/PROSPERO/#joinuppage). Public Library of Science 2023-02-03 /pmc/articles/PMC9897544/ /pubmed/36735725 http://dx.doi.org/10.1371/journal.pone.0271712 Text en © 2023 Cao et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Study Protocol Cao, Rui Lu, Jiaxing Chen, Zhao Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis |
title | Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis |
title_full | Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis |
title_fullStr | Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis |
title_full_unstemmed | Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis |
title_short | Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis |
title_sort | biologics for pediatric atopic dermatitis: a protocol of a systematic review and meta-analysis |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897544/ https://www.ncbi.nlm.nih.gov/pubmed/36735725 http://dx.doi.org/10.1371/journal.pone.0271712 |
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