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Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction

High levels of lactate are positively associated with the prognosis and mortality in patients with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in cardiac fibrosis. Here, we report that lactate exerts a previously unknown function that increases cardiac fibros...

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Detalles Bibliográficos
Autores principales:	Fan, Min, Yang, Kun, Wang, Xiaohui, Chen, Linjian, Gill, P. Spencer, Ha, Tuanzhu, Liu, Li, Lewis, Nicole H., Williams, David L., Li, Chuanfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897666/ https://www.ncbi.nlm.nih.gov/pubmed/36735787 http://dx.doi.org/10.1126/sciadv.adc9465

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