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Do Platelet-Rich Plasma Injections for Knee Osteoarthritis Work?

Background: Recent evidence suggests a benefit in platelet-rich plasma injections (PRP) for the knee in the management of mild to moderate osteoarthritis (OA). There is a reported reduction in pain, stiffness, and improved function. However, there is very little level-one literature available that s...

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Autores principales: Shahid, Abbas, Malik, Asad, Bukhari, Ali, Shaikh, Adil, Rutherford, Jill, Barkatali, Bilal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897683/
https://www.ncbi.nlm.nih.gov/pubmed/36751575
http://dx.doi.org/10.7759/cureus.34533
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author Shahid, Abbas
Malik, Asad
Bukhari, Ali
Shaikh, Adil
Rutherford, Jill
Barkatali, Bilal
author_facet Shahid, Abbas
Malik, Asad
Bukhari, Ali
Shaikh, Adil
Rutherford, Jill
Barkatali, Bilal
author_sort Shahid, Abbas
collection PubMed
description Background: Recent evidence suggests a benefit in platelet-rich plasma injections (PRP) for the knee in the management of mild to moderate osteoarthritis (OA). There is a reported reduction in pain, stiffness, and improved function. However, there is very little level-one literature available that supports this practice and conclusively proves a benefit gained throughout the course. Three main randomized control trials (RCTs) conducted in North America are often referenced and cited to prove their efficacy. This study aimed to look at the outcomes of patients having undergone this treatment to determine if there was any benefit. Aims: This study aimed to determine if PRP injections administered in patients with knee OA over a six to eight-week time period demonstrated any benefit. Methods: The Western Ontario and McMaster Universities arthritis index (WOMAC) tool was used before each of the three PRP injections over the six to eight-week period, and six weeks after the final injection in 31 patients. Each injection was given spaced two to three weeks apart. The outcomes observed were pain, stiffness, and physical function, and the total WOMAC score was calculated. Results: The third injection showed a reduction in total WOMAC score, pain, stiffness, and physical function by 16.36%, 16.37%, 5.12%, and 18.03%, respectively. However, all scores returned close to baseline at the sixth-week follow-up post treatment. Conclusion: Results showed a trend of reduction in the WOMAC score. However, they are overall indicative of a placebo effect from the injections. Further studies are needed to explore whether the grade of OA and patients’ weight have a significant impact on the results.
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spelling pubmed-98976832023-02-06 Do Platelet-Rich Plasma Injections for Knee Osteoarthritis Work? Shahid, Abbas Malik, Asad Bukhari, Ali Shaikh, Adil Rutherford, Jill Barkatali, Bilal Cureus Pain Management Background: Recent evidence suggests a benefit in platelet-rich plasma injections (PRP) for the knee in the management of mild to moderate osteoarthritis (OA). There is a reported reduction in pain, stiffness, and improved function. However, there is very little level-one literature available that supports this practice and conclusively proves a benefit gained throughout the course. Three main randomized control trials (RCTs) conducted in North America are often referenced and cited to prove their efficacy. This study aimed to look at the outcomes of patients having undergone this treatment to determine if there was any benefit. Aims: This study aimed to determine if PRP injections administered in patients with knee OA over a six to eight-week time period demonstrated any benefit. Methods: The Western Ontario and McMaster Universities arthritis index (WOMAC) tool was used before each of the three PRP injections over the six to eight-week period, and six weeks after the final injection in 31 patients. Each injection was given spaced two to three weeks apart. The outcomes observed were pain, stiffness, and physical function, and the total WOMAC score was calculated. Results: The third injection showed a reduction in total WOMAC score, pain, stiffness, and physical function by 16.36%, 16.37%, 5.12%, and 18.03%, respectively. However, all scores returned close to baseline at the sixth-week follow-up post treatment. Conclusion: Results showed a trend of reduction in the WOMAC score. However, they are overall indicative of a placebo effect from the injections. Further studies are needed to explore whether the grade of OA and patients’ weight have a significant impact on the results. Cureus 2023-02-02 /pmc/articles/PMC9897683/ /pubmed/36751575 http://dx.doi.org/10.7759/cureus.34533 Text en Copyright © 2023, Shahid et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pain Management
Shahid, Abbas
Malik, Asad
Bukhari, Ali
Shaikh, Adil
Rutherford, Jill
Barkatali, Bilal
Do Platelet-Rich Plasma Injections for Knee Osteoarthritis Work?
title Do Platelet-Rich Plasma Injections for Knee Osteoarthritis Work?
title_full Do Platelet-Rich Plasma Injections for Knee Osteoarthritis Work?
title_fullStr Do Platelet-Rich Plasma Injections for Knee Osteoarthritis Work?
title_full_unstemmed Do Platelet-Rich Plasma Injections for Knee Osteoarthritis Work?
title_short Do Platelet-Rich Plasma Injections for Knee Osteoarthritis Work?
title_sort do platelet-rich plasma injections for knee osteoarthritis work?
topic Pain Management
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897683/
https://www.ncbi.nlm.nih.gov/pubmed/36751575
http://dx.doi.org/10.7759/cureus.34533
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