ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using both larval and adult zebrafish models of hepatocellular carcinoma (HCC), in which the expression of an inducible mutant kras transgene (kras(G12V)) driv...

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Detalles Bibliográficos
Autores principales: Morgan, Kimberly J, Doggett, Karen, Geng, Fansuo, Mieruszynski, Stephen, Whitehead, Lachlan, Smith, Kelly A, Hogan, Benjamin M, Simons, Cas, Baillie, Gregory J, Molania, Ramyar, Papenfuss, Anthony T, Hall, Thomas E, Ober, Elke A, Stainier, Didier YR, Gong, Zhiyuan, Heath, Joan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897728/
https://www.ncbi.nlm.nih.gov/pubmed/36648336
http://dx.doi.org/10.7554/eLife.73407

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