Assessments of CYP‑inhibition‑based drug–drug interaction between vonoprazan and poziotinib in vitro and in vivo

CONTEXT: Poziotinib and vonoprazan are two drugs mainly metabolized by CYP3A4. However, the drug-drug interaction between them is unknown. OBJECTIVE: To study the interaction mechanism and pharmacokinetics of poziotinib on vonoprazan. MATERIALS AND METHODS: In vitro experiments were performed with r...

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Detalles Bibliográficos
Autores principales: Zhou, Shan, Zhao, Fang-Ling, Wang, Shuang-Hu, Wang, Yi-Ran, Hong, Yun, Zhou, Quan, Geng, Pei-Wu, Luo, Qing-Feng, Cai, Jian-Ping, Dai, Da-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897767/
https://www.ncbi.nlm.nih.gov/pubmed/36728978
http://dx.doi.org/10.1080/13880209.2023.2173253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897767/
https://www.ncbi.nlm.nih.gov/pubmed/36728978
http://dx.doi.org/10.1080/13880209.2023.2173253

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