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Advances in imaging techniques to assess kidney fibrosis

As a sign of chronic kidney disease (CKD) progression, renal fibrosis is an irreversible and alarming pathological change. The accurate diagnosis of renal fibrosis depends on the widely used renal biopsy, but this diagnostic modality is invasive and can easily lead to sampling error. With the develo...

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Autores principales: Jiang, Buchun, Liu, Fei, Fu, Haidong, Mao, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897785/
https://www.ncbi.nlm.nih.gov/pubmed/36723057
http://dx.doi.org/10.1080/0886022X.2023.2171887
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author Jiang, Buchun
Liu, Fei
Fu, Haidong
Mao, Jianhua
author_facet Jiang, Buchun
Liu, Fei
Fu, Haidong
Mao, Jianhua
author_sort Jiang, Buchun
collection PubMed
description As a sign of chronic kidney disease (CKD) progression, renal fibrosis is an irreversible and alarming pathological change. The accurate diagnosis of renal fibrosis depends on the widely used renal biopsy, but this diagnostic modality is invasive and can easily lead to sampling error. With the development of imaging techniques, an increasing number of noninvasive imaging techniques, such as multipara meter magnetic resonance imaging (MRI) and ultrasound elastography, have gained attention in assessing kidney fibrosis. Depending on their ability to detect changes in tissue stiffness and diffusion of water molecules, ultrasound elastography and some MRI techniques can indirectly assess the degree of fibrosis. The worsening of renal tissue oxygenation and perfusion measured by blood oxygenation level-dependent MRI and arterial spin labeling MRI separately is also an indirect reflection of renal fibrosis. Objective and quantitative indices of fibrosis may be available in the future by using novel techniques, such as photoacoustic imaging and fluorescence microscopy. However, these imaging techniques are susceptible to interference or may not be convenient. Due to the lack of sufficient specificity and sensitivity, these imaging techniques are neither widely accepted nor proposed by clinicians. These obstructions must be overcome by conducting technology research and more prospective studies. In this review, we emphasize the recent advancement of these noninvasive imaging techniques and provide clinicians a continuously updated perspective on the assessment of kidney fibrosis.
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spelling pubmed-98977852023-02-04 Advances in imaging techniques to assess kidney fibrosis Jiang, Buchun Liu, Fei Fu, Haidong Mao, Jianhua Ren Fail State-of-the-Art Review As a sign of chronic kidney disease (CKD) progression, renal fibrosis is an irreversible and alarming pathological change. The accurate diagnosis of renal fibrosis depends on the widely used renal biopsy, but this diagnostic modality is invasive and can easily lead to sampling error. With the development of imaging techniques, an increasing number of noninvasive imaging techniques, such as multipara meter magnetic resonance imaging (MRI) and ultrasound elastography, have gained attention in assessing kidney fibrosis. Depending on their ability to detect changes in tissue stiffness and diffusion of water molecules, ultrasound elastography and some MRI techniques can indirectly assess the degree of fibrosis. The worsening of renal tissue oxygenation and perfusion measured by blood oxygenation level-dependent MRI and arterial spin labeling MRI separately is also an indirect reflection of renal fibrosis. Objective and quantitative indices of fibrosis may be available in the future by using novel techniques, such as photoacoustic imaging and fluorescence microscopy. However, these imaging techniques are susceptible to interference or may not be convenient. Due to the lack of sufficient specificity and sensitivity, these imaging techniques are neither widely accepted nor proposed by clinicians. These obstructions must be overcome by conducting technology research and more prospective studies. In this review, we emphasize the recent advancement of these noninvasive imaging techniques and provide clinicians a continuously updated perspective on the assessment of kidney fibrosis. Taylor & Francis 2023-02-01 /pmc/articles/PMC9897785/ /pubmed/36723057 http://dx.doi.org/10.1080/0886022X.2023.2171887 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle State-of-the-Art Review
Jiang, Buchun
Liu, Fei
Fu, Haidong
Mao, Jianhua
Advances in imaging techniques to assess kidney fibrosis
title Advances in imaging techniques to assess kidney fibrosis
title_full Advances in imaging techniques to assess kidney fibrosis
title_fullStr Advances in imaging techniques to assess kidney fibrosis
title_full_unstemmed Advances in imaging techniques to assess kidney fibrosis
title_short Advances in imaging techniques to assess kidney fibrosis
title_sort advances in imaging techniques to assess kidney fibrosis
topic State-of-the-Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897785/
https://www.ncbi.nlm.nih.gov/pubmed/36723057
http://dx.doi.org/10.1080/0886022X.2023.2171887
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