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Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho

BACKGROUND: Peritoneal fibrosis caused by long-term peritoneal dialysis (PD) is the main reason why patients withdraw from PD treatment. Lipid accumulation in the peritoneum was shown to participate in fibrosis, and klotho is a molecule involved in lipid metabolism. GSK343 (enhancer of zeste 2 polyc...

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Detalles Bibliográficos
Autores principales:	Wang, Qinglian, Sun, Jingshu, Wang, Rong, Sun, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897791/ https://www.ncbi.nlm.nih.gov/pubmed/36724065 http://dx.doi.org/10.1080/0886022X.2022.2149411

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