NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma

In clear cell renal cell carcinoma (ccRCC), activation of hypoxic signaling induces NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) expression. Over 90% of ccRCCs exhibit overexpression of NDUFA4L2, which we previously showed contributes to ccRCC proliferation and survival. T...

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Detalles Bibliográficos
Autores principales: Kubala, Jaclyn M., Laursen, Kristian B., Schreiner, Ryan, Williams, Ryan M., van der Mijn, Johannes C., Crowley, Michael J., Mongan, Nigel P., Nanus, David M., Heller, Daniel A., Gudas, Lorraine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897797/
https://www.ncbi.nlm.nih.gov/pubmed/36722045
http://dx.doi.org/10.1080/15384047.2023.2170669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897797/
https://www.ncbi.nlm.nih.gov/pubmed/36722045
http://dx.doi.org/10.1080/15384047.2023.2170669

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