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Epidemiologic characteristics and clinical features of patients with monkeypox virus infection from a hospital in Peru between July and September 2022

OBJECTIVES: Monkeypox (Mpox) recent outbreak has changed in terms of predominant transmission route and typical presentation. Describing current epidemiological and clinical characteristics is crucial to identifying cases and halting transmission. METHODS: An observational study was conducted at a P...

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Autores principales: Sihuincha Maldonado, Moisés, Lucchetti, Aldo Javier, Paredes Pacheco, Raisa Alessandra, Martínez Cevallos, Leonel Christian, Zumaeta Saavedra, Enrique Uless, Ponce Zapata, Lourdes Renatta, Lizarbe Huayta, Fernando Alonso, Matos Prado, Eduardo Demetrio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897875/
https://www.ncbi.nlm.nih.gov/pubmed/36740013
http://dx.doi.org/10.1016/j.ijid.2023.01.045
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author Sihuincha Maldonado, Moisés
Lucchetti, Aldo Javier
Paredes Pacheco, Raisa Alessandra
Martínez Cevallos, Leonel Christian
Zumaeta Saavedra, Enrique Uless
Ponce Zapata, Lourdes Renatta
Lizarbe Huayta, Fernando Alonso
Matos Prado, Eduardo Demetrio
author_facet Sihuincha Maldonado, Moisés
Lucchetti, Aldo Javier
Paredes Pacheco, Raisa Alessandra
Martínez Cevallos, Leonel Christian
Zumaeta Saavedra, Enrique Uless
Ponce Zapata, Lourdes Renatta
Lizarbe Huayta, Fernando Alonso
Matos Prado, Eduardo Demetrio
author_sort Sihuincha Maldonado, Moisés
collection PubMed
description OBJECTIVES: Monkeypox (Mpox) recent outbreak has changed in terms of predominant transmission route and typical presentation. Describing current epidemiological and clinical characteristics is crucial to identifying cases and halting transmission. METHODS: An observational study was conducted at a Peruvian tertiary-level hospital and included all individuals with Mpox virus infection between July 01 and September 03, 2022. RESULTS: Among 205 confirmed cases, 99% (202/205) were men, 94% (192/205) were men who have sex with men or bisexual, and 66% (136/205) were living with HIV. Regarding sexual behavior, 87% (179/205) had a sexual encounter 21 days before consultation, although only 8% (17/205) identified sexual contact with a Mpox confirmed case; 65% (133/205) had sexual intercourse with casual partners, 55% (112/205) reported a last sexual partner unknown, and 21.5% (44/205) continued having sexual intercourse with symptoms. Systemic symptoms were fever (162/205, 79%), malaise (123/205, 60%), headache (119/205, 58%), fatigue (105/205, 52%), and lymphadenopathy (111/205, 54%). The distribution of skin lesions was generalized (166/205, 81%), located in the anogenital area (160/205, 78%), polymorphic (174/205, 85%), and it was the first symptom identified in 46% (94/205) of cases. Overall, 10% (21/205) required hospitalization, of whom 85.7% (18/205) have HIV infection. Complications included bacterial superinfection (n = 18), proctitis (n = 6), balanitis (n = 4), and necrosis of skin lesions (n = 3). CONCLUSION: In 2022, Mpox mainly affects men who have sex with men and People living with HIV/AIDS. It presents with skin lesions localized to the anogenital area and can lead to severe complications requiring hospitalization.
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spelling pubmed-98978752023-02-06 Epidemiologic characteristics and clinical features of patients with monkeypox virus infection from a hospital in Peru between July and September 2022 Sihuincha Maldonado, Moisés Lucchetti, Aldo Javier Paredes Pacheco, Raisa Alessandra Martínez Cevallos, Leonel Christian Zumaeta Saavedra, Enrique Uless Ponce Zapata, Lourdes Renatta Lizarbe Huayta, Fernando Alonso Matos Prado, Eduardo Demetrio Int J Infect Dis Article OBJECTIVES: Monkeypox (Mpox) recent outbreak has changed in terms of predominant transmission route and typical presentation. Describing current epidemiological and clinical characteristics is crucial to identifying cases and halting transmission. METHODS: An observational study was conducted at a Peruvian tertiary-level hospital and included all individuals with Mpox virus infection between July 01 and September 03, 2022. RESULTS: Among 205 confirmed cases, 99% (202/205) were men, 94% (192/205) were men who have sex with men or bisexual, and 66% (136/205) were living with HIV. Regarding sexual behavior, 87% (179/205) had a sexual encounter 21 days before consultation, although only 8% (17/205) identified sexual contact with a Mpox confirmed case; 65% (133/205) had sexual intercourse with casual partners, 55% (112/205) reported a last sexual partner unknown, and 21.5% (44/205) continued having sexual intercourse with symptoms. Systemic symptoms were fever (162/205, 79%), malaise (123/205, 60%), headache (119/205, 58%), fatigue (105/205, 52%), and lymphadenopathy (111/205, 54%). The distribution of skin lesions was generalized (166/205, 81%), located in the anogenital area (160/205, 78%), polymorphic (174/205, 85%), and it was the first symptom identified in 46% (94/205) of cases. Overall, 10% (21/205) required hospitalization, of whom 85.7% (18/205) have HIV infection. Complications included bacterial superinfection (n = 18), proctitis (n = 6), balanitis (n = 4), and necrosis of skin lesions (n = 3). CONCLUSION: In 2022, Mpox mainly affects men who have sex with men and People living with HIV/AIDS. It presents with skin lesions localized to the anogenital area and can lead to severe complications requiring hospitalization. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2023-04 2023-02-04 /pmc/articles/PMC9897875/ /pubmed/36740013 http://dx.doi.org/10.1016/j.ijid.2023.01.045 Text en © 2023 The Authors Elsevier has created a Monkeypox Information Center (https://www.elsevier.com/connect/monkeypox-information-center) in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.
spellingShingle Article
Sihuincha Maldonado, Moisés
Lucchetti, Aldo Javier
Paredes Pacheco, Raisa Alessandra
Martínez Cevallos, Leonel Christian
Zumaeta Saavedra, Enrique Uless
Ponce Zapata, Lourdes Renatta
Lizarbe Huayta, Fernando Alonso
Matos Prado, Eduardo Demetrio
Epidemiologic characteristics and clinical features of patients with monkeypox virus infection from a hospital in Peru between July and September 2022
title Epidemiologic characteristics and clinical features of patients with monkeypox virus infection from a hospital in Peru between July and September 2022
title_full Epidemiologic characteristics and clinical features of patients with monkeypox virus infection from a hospital in Peru between July and September 2022
title_fullStr Epidemiologic characteristics and clinical features of patients with monkeypox virus infection from a hospital in Peru between July and September 2022
title_full_unstemmed Epidemiologic characteristics and clinical features of patients with monkeypox virus infection from a hospital in Peru between July and September 2022
title_short Epidemiologic characteristics and clinical features of patients with monkeypox virus infection from a hospital in Peru between July and September 2022
title_sort epidemiologic characteristics and clinical features of patients with monkeypox virus infection from a hospital in peru between july and september 2022
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897875/
https://www.ncbi.nlm.nih.gov/pubmed/36740013
http://dx.doi.org/10.1016/j.ijid.2023.01.045
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