A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients

The insertion site of the internal tandem duplications (ITDs) in the FLT3 gene affects the sensitivity to tyrosine kinase inhibitors (TKIs) therapy in acute myeloid leukemia (AML). Patients with the ITD in the tyrosine kinase domain lack effective therapeutic options. Here, to identify genotype-driv...

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Detalles Bibliográficos
Autores principales: Massacci, Giorgia, Venafra, Veronica, Latini, Sara, Bica, Valeria, Pugliese, Giusj Monia, Graziosi, Simone, Klingelhuber, Felix, Krahmer, Natalie, Fischer, Thomas, Mougiakakos, Dimitrios, Boettcher, Martin, Perfetto, Livia, Sacco, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898030/
https://www.ncbi.nlm.nih.gov/pubmed/36509894
http://dx.doi.org/10.1038/s41375-022-01785-w

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