P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways

How bone marrow niches regulate leukemogenic activities of leukemia-initiating cells (LICs) is unclear. The present study revealed that the metabolic niche component, ATP, efficiently induced ion influx in LICs through its ligand-gated ion channel, P2X1. P2X1 deletion impaired LIC self-renewal capac...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Xiaoxiao, Xu, Yilu, Huang, Dan, Yu, Zhuo, Yu, Jing, Xie, Li, Liu, Ligen, Yu, Ye, Chen, Chiqi, Wan, Jiangbo, Zhang, Yaping, Zheng, Junke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898031/
https://www.ncbi.nlm.nih.gov/pubmed/36418376
http://dx.doi.org/10.1038/s41375-022-01759-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898031/
https://www.ncbi.nlm.nih.gov/pubmed/36418376
http://dx.doi.org/10.1038/s41375-022-01759-y

Ejemplares similares