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P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways

How bone marrow niches regulate leukemogenic activities of leukemia-initiating cells (LICs) is unclear. The present study revealed that the metabolic niche component, ATP, efficiently induced ion influx in LICs through its ligand-gated ion channel, P2X1. P2X1 deletion impaired LIC self-renewal capac...

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Detalles Bibliográficos
Autores principales:	He, Xiaoxiao, Xu, Yilu, Huang, Dan, Yu, Zhuo, Yu, Jing, Xie, Li, Liu, Ligen, Yu, Ye, Chen, Chiqi, Wan, Jiangbo, Zhang, Yaping, Zheng, Junke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898031/ https://www.ncbi.nlm.nih.gov/pubmed/36418376 http://dx.doi.org/10.1038/s41375-022-01759-y

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