Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis

Mitochondrial DNA (mtDNA) released through protein oligomers, such as voltage-dependent anion channel 1 (VDAC1), triggers innate immune activation and thus contributes to liver fibrosis. Here, we investigated the role of Parkin, an important regulator of mitochondria, and its regulation of VDAC1-med...

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Detalles Bibliográficos
Autores principales: Wu, Ne N., Wang, Lifeng, Wang, Lu, Xu, Xihui, Lopaschuk, Gary D., Zhang, Yingmei, Ren, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898252/
https://www.ncbi.nlm.nih.gov/pubmed/36658227
http://dx.doi.org/10.1038/s12276-022-00923-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898252/
https://www.ncbi.nlm.nih.gov/pubmed/36658227
http://dx.doi.org/10.1038/s12276-022-00923-9

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