SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis

Mitochondrial dysfunction plays a major role in the development of intervertebral disc degeneration (IDD). Sirtuin 5 (SIRT5) participates in the maintenance of mitochondrial homeostasis through its desuccinylase activity. However, it is still unclear whether succinylation or SIRT5 is involved in the...

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Detalles Bibliográficos
Autores principales: Mao, Jianxin, Wang, Di, Wang, Dong, Wu, Qi, Shang, Qiliang, Gao, Chu, Wang, Huanbo, Wang, Han, Du, Mu, Peng, Pandi, Jia, Haoruo, Xu, Xiaolong, Wang, Jie, Yang, Liu, Luo, Zhuojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898264/
https://www.ncbi.nlm.nih.gov/pubmed/36653443
http://dx.doi.org/10.1038/s12276-023-00928-y

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