Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis

Metformin is the biguanide of hepatic insulin sensitizer for patients with non-alcohol fatty liver disease (NAFLD). Findings regarding its efficacy in restoring blood lipids and liver histology have been contradictory. In this study, we explore metformin’s preventive effects on NAFLD in leptin-insen...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Bingli, Xu, Jingyuan, Lu, Linyao, Gao, Lili, Zhu, Shengjuan, Sui, Yi, Cao, Ting, Yang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898507/
https://www.ncbi.nlm.nih.gov/pubmed/36737598
http://dx.doi.org/10.1038/s41419-023-05623-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898507/
https://www.ncbi.nlm.nih.gov/pubmed/36737598
http://dx.doi.org/10.1038/s41419-023-05623-4

Ejemplares similares