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Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis

Gastric cancer (GC) is one of the most common and deadly cancers in the world. It is a multifactorial disease highly influenced by environmental factors, which include radiation, smoking, diet, and infectious pathogens. Accumulating evidence suggests that epigenetic regulators are frequently altered...

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Autores principales: Loe, Adrian Kwan Ho, Zhu, Lexin, Kim, Tae-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898530/
https://www.ncbi.nlm.nih.gov/pubmed/36653445
http://dx.doi.org/10.1038/s12276-023-00926-0
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author Loe, Adrian Kwan Ho
Zhu, Lexin
Kim, Tae-Hee
author_facet Loe, Adrian Kwan Ho
Zhu, Lexin
Kim, Tae-Hee
author_sort Loe, Adrian Kwan Ho
collection PubMed
description Gastric cancer (GC) is one of the most common and deadly cancers in the world. It is a multifactorial disease highly influenced by environmental factors, which include radiation, smoking, diet, and infectious pathogens. Accumulating evidence suggests that epigenetic regulators are frequently altered in GC, playing critical roles in gastric tumorigenesis. Epigenetic regulation involves DNA methylation, histone modification, and noncoding RNAs. While it is known that environmental factors cause widespread alterations in DNA methylation, promoting carcinogenesis, the chromatin- and noncoding RNA-mediated mechanisms of gastric tumorigenesis are still poorly understood. In this review, we focus on discussing recent discoveries addressing the roles of histone modifiers and noncoding RNAs and the mechanisms of their interactions in gastric tumorigenesis. A better understanding of epigenetic regulation would likely facilitate the development of novel therapeutic approaches targeting specific epigenetic regulators in GC.
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spelling pubmed-98985302023-02-16 Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis Loe, Adrian Kwan Ho Zhu, Lexin Kim, Tae-Hee Exp Mol Med Review Article Gastric cancer (GC) is one of the most common and deadly cancers in the world. It is a multifactorial disease highly influenced by environmental factors, which include radiation, smoking, diet, and infectious pathogens. Accumulating evidence suggests that epigenetic regulators are frequently altered in GC, playing critical roles in gastric tumorigenesis. Epigenetic regulation involves DNA methylation, histone modification, and noncoding RNAs. While it is known that environmental factors cause widespread alterations in DNA methylation, promoting carcinogenesis, the chromatin- and noncoding RNA-mediated mechanisms of gastric tumorigenesis are still poorly understood. In this review, we focus on discussing recent discoveries addressing the roles of histone modifiers and noncoding RNAs and the mechanisms of their interactions in gastric tumorigenesis. A better understanding of epigenetic regulation would likely facilitate the development of novel therapeutic approaches targeting specific epigenetic regulators in GC. Nature Publishing Group UK 2023-01-19 /pmc/articles/PMC9898530/ /pubmed/36653445 http://dx.doi.org/10.1038/s12276-023-00926-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Loe, Adrian Kwan Ho
Zhu, Lexin
Kim, Tae-Hee
Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
title Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
title_full Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
title_fullStr Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
title_full_unstemmed Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
title_short Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
title_sort chromatin and noncoding rna-mediated mechanisms of gastric tumorigenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898530/
https://www.ncbi.nlm.nih.gov/pubmed/36653445
http://dx.doi.org/10.1038/s12276-023-00926-0
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