Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance

Increased von Willebrand factor (VWF) clearance plays a key role in the pathogenesis of type 1 and type 2 von Willebrand disease (VWD). However, the pathological mechanisms involved in patients with mild to moderate reductions in plasma VWF:Ag (range, 30-50 IU/dL; low VWF) remain poorly understood....

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Detalles Bibliográficos
Autores principales: Doherty, Dearbhla, Michelle Lavin, Byrne, Mary, Nolan, Margaret, O’Sullivan, Jamie M., Ryan, Kevin, O’Connell, Niamh M., Haberichter, Sandra L., Christopherson, Pamela A., Di Paola, Jorge, James, Paula D., O’Donnell, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898599/
https://www.ncbi.nlm.nih.gov/pubmed/35523118
http://dx.doi.org/10.1182/bloodadvances.2022007340

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