A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin

Collagen triple helices are critical in the function of mannan-binding lectin (MBL), an oligomeric recognition molecule in complement activation. The MBL collagen regions form complexes with the serine proteases MASP-1 and MASP-2 in order to activate complement, and mutations lead to common immunode...

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Detalles Bibliográficos
Autores principales: Iqbal, Hina, Fung, Ka Wai, Gor, Jayesh, Bishop, Anthony C., Makhatadze, George I., Brodsky, Barbara, Perkins, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898670/
https://www.ncbi.nlm.nih.gov/pubmed/36528062
http://dx.doi.org/10.1016/j.jbc.2022.102799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898670/
https://www.ncbi.nlm.nih.gov/pubmed/36528062
http://dx.doi.org/10.1016/j.jbc.2022.102799

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