Cargando…
A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin
Collagen triple helices are critical in the function of mannan-binding lectin (MBL), an oligomeric recognition molecule in complement activation. The MBL collagen regions form complexes with the serine proteases MASP-1 and MASP-2 in order to activate complement, and mutations lead to common immunode...
Autores principales: | Iqbal, Hina, Fung, Ka Wai, Gor, Jayesh, Bishop, Anthony C., Makhatadze, George I., Brodsky, Barbara, Perkins, Stephen J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898670/ https://www.ncbi.nlm.nih.gov/pubmed/36528062 http://dx.doi.org/10.1016/j.jbc.2022.102799 |
Ejemplares similares
-
Non-linearity of the collagen triple helix in solution and implications for collagen function
por: Walker, Kenneth T., et al.
Publicado: (2017) -
Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation
por: Nan, Ruodan, et al.
Publicado: (2017) -
Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement
por: Miller, Ami, et al.
Publicado: (2012) -
Complement Receptor 1/Cd35 Is a Receptor for Mannan-Binding Lectin
por: Ghiran, Ionita, et al.
Publicado: (2000) -
Mannan-Binding Lectin in Cardiovascular Disease
por: Pągowska-Klimek, Izabela, et al.
Publicado: (2014)