Cargando…

SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies

Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-2 infection and transmission, but both reduce the risk of severe COVID-19. To generate insights into optimal vaccination strategies for prevention of severe COVID-19 in the population, we extended a Suscepti...

Descripción completa

Detalles Bibliográficos
Autores principales: Beukenhorst, Anna L., Koch, Clarissa M., Hadjichrysanthou, Christoforos, Alter, Galit, de Wolf, Frank, Anderson, Roy M., Goudsmit, Jaap
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898703/
https://www.ncbi.nlm.nih.gov/pubmed/36738380
http://dx.doi.org/10.1007/s10654-023-00965-x
_version_ 1784882483645382656
author Beukenhorst, Anna L.
Koch, Clarissa M.
Hadjichrysanthou, Christoforos
Alter, Galit
de Wolf, Frank
Anderson, Roy M.
Goudsmit, Jaap
author_facet Beukenhorst, Anna L.
Koch, Clarissa M.
Hadjichrysanthou, Christoforos
Alter, Galit
de Wolf, Frank
Anderson, Roy M.
Goudsmit, Jaap
author_sort Beukenhorst, Anna L.
collection PubMed
description Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-2 infection and transmission, but both reduce the risk of severe COVID-19. To generate insights into optimal vaccination strategies for prevention of severe COVID-19 in the population, we extended a Susceptible-Exposed-Infectious-Removed (SEIR) mathematical model to compare the impact of vaccines that are highly protective against severe COVID-19 but not against infection and transmission, with those that block SARS-CoV-2 infection. Our analysis shows that vaccination strategies focusing on the prevention of severe COVID-19 are more effective than those focusing on creating of herd immunity. Key uncertainties that would affect the choice of vaccination strategies are: (1) the duration of protection against severe disease, (2) the protection against severe disease from variants that escape vaccine-induced immunity, (3) the incidence of long-COVID and level of protection provided by the vaccine, and (4) the rate of serious adverse events following vaccination, stratified by demographic variables.
format Online
Article
Text
id pubmed-9898703
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-98987032023-02-06 SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies Beukenhorst, Anna L. Koch, Clarissa M. Hadjichrysanthou, Christoforos Alter, Galit de Wolf, Frank Anderson, Roy M. Goudsmit, Jaap Eur J Epidemiol Essay Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-2 infection and transmission, but both reduce the risk of severe COVID-19. To generate insights into optimal vaccination strategies for prevention of severe COVID-19 in the population, we extended a Susceptible-Exposed-Infectious-Removed (SEIR) mathematical model to compare the impact of vaccines that are highly protective against severe COVID-19 but not against infection and transmission, with those that block SARS-CoV-2 infection. Our analysis shows that vaccination strategies focusing on the prevention of severe COVID-19 are more effective than those focusing on creating of herd immunity. Key uncertainties that would affect the choice of vaccination strategies are: (1) the duration of protection against severe disease, (2) the protection against severe disease from variants that escape vaccine-induced immunity, (3) the incidence of long-COVID and level of protection provided by the vaccine, and (4) the rate of serious adverse events following vaccination, stratified by demographic variables. Springer Netherlands 2023-02-04 2023 /pmc/articles/PMC9898703/ /pubmed/36738380 http://dx.doi.org/10.1007/s10654-023-00965-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Essay
Beukenhorst, Anna L.
Koch, Clarissa M.
Hadjichrysanthou, Christoforos
Alter, Galit
de Wolf, Frank
Anderson, Roy M.
Goudsmit, Jaap
SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies
title SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies
title_full SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies
title_fullStr SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies
title_full_unstemmed SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies
title_short SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies
title_sort sars-cov-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies
topic Essay
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898703/
https://www.ncbi.nlm.nih.gov/pubmed/36738380
http://dx.doi.org/10.1007/s10654-023-00965-x
work_keys_str_mv AT beukenhorstannal sarscov2elicitsnonsterilizingimmunityandevadesvaccineinducedimmunityimplicationsforfuturevaccinationstrategies
AT kochclarissam sarscov2elicitsnonsterilizingimmunityandevadesvaccineinducedimmunityimplicationsforfuturevaccinationstrategies
AT hadjichrysanthouchristoforos sarscov2elicitsnonsterilizingimmunityandevadesvaccineinducedimmunityimplicationsforfuturevaccinationstrategies
AT altergalit sarscov2elicitsnonsterilizingimmunityandevadesvaccineinducedimmunityimplicationsforfuturevaccinationstrategies
AT dewolffrank sarscov2elicitsnonsterilizingimmunityandevadesvaccineinducedimmunityimplicationsforfuturevaccinationstrategies
AT andersonroym sarscov2elicitsnonsterilizingimmunityandevadesvaccineinducedimmunityimplicationsforfuturevaccinationstrategies
AT goudsmitjaap sarscov2elicitsnonsterilizingimmunityandevadesvaccineinducedimmunityimplicationsforfuturevaccinationstrategies