High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei

In this study, we examined a cohort of Japanese patients with acute myeloid leukemia (AML) with cup-like nuclei. In particular, we attempted to provide a detailed definition of the clinical features of AML with cup-like nuclei. The clinical records of patients diagnosed with de novo AML were collect...

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Autores principales: Watanabe, Naoki, Kitahara, Hideaki, Honda, Tadahiro, Iwasaki, Hisayo, Iwao, Noriaki, Komatsu, Norio, Koike, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JSLRT 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898714/
https://www.ncbi.nlm.nih.gov/pubmed/36575001
http://dx.doi.org/10.3960/jslrt.22020
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author Watanabe, Naoki
Kitahara, Hideaki
Honda, Tadahiro
Iwasaki, Hisayo
Iwao, Noriaki
Komatsu, Norio
Koike, Michiaki
author_facet Watanabe, Naoki
Kitahara, Hideaki
Honda, Tadahiro
Iwasaki, Hisayo
Iwao, Noriaki
Komatsu, Norio
Koike, Michiaki
author_sort Watanabe, Naoki
collection PubMed
description In this study, we examined a cohort of Japanese patients with acute myeloid leukemia (AML) with cup-like nuclei. In particular, we attempted to provide a detailed definition of the clinical features of AML with cup-like nuclei. The clinical records of patients diagnosed with de novo AML were collected retrospectively. We showed that approximately 23% of all patients with AML diagnosed during the study period had AML with cup-like nuclei. All three cup-like AML cases had FLT3-ITD mutations. In addition, we reported a high incidence of disseminated intravascular coagulation and acute cerebral infarction in patients with AML with cup-like nuclei. Our results show that AML with cup-like nuclei may be more common than expected. Due to these unique characteristics, recognition of this morphology is recommended.
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spelling pubmed-98987142023-02-13 High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei Watanabe, Naoki Kitahara, Hideaki Honda, Tadahiro Iwasaki, Hisayo Iwao, Noriaki Komatsu, Norio Koike, Michiaki J Clin Exp Hematop Case Report In this study, we examined a cohort of Japanese patients with acute myeloid leukemia (AML) with cup-like nuclei. In particular, we attempted to provide a detailed definition of the clinical features of AML with cup-like nuclei. The clinical records of patients diagnosed with de novo AML were collected retrospectively. We showed that approximately 23% of all patients with AML diagnosed during the study period had AML with cup-like nuclei. All three cup-like AML cases had FLT3-ITD mutations. In addition, we reported a high incidence of disseminated intravascular coagulation and acute cerebral infarction in patients with AML with cup-like nuclei. Our results show that AML with cup-like nuclei may be more common than expected. Due to these unique characteristics, recognition of this morphology is recommended. JSLRT 2022-12-28 /pmc/articles/PMC9898714/ /pubmed/36575001 http://dx.doi.org/10.3960/jslrt.22020 Text en © 2022 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License.
spellingShingle Case Report
Watanabe, Naoki
Kitahara, Hideaki
Honda, Tadahiro
Iwasaki, Hisayo
Iwao, Noriaki
Komatsu, Norio
Koike, Michiaki
High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei
title High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei
title_full High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei
title_fullStr High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei
title_full_unstemmed High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei
title_short High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei
title_sort high incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898714/
https://www.ncbi.nlm.nih.gov/pubmed/36575001
http://dx.doi.org/10.3960/jslrt.22020
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