Cargando…
MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21)
We describe two follicular lymphoma (FL) patients with MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit translocations. The first patient (case 1) was a man in his 30s who presented with stage IV disease with leukemic manifestation. The second patient (case 2) was a man in his 60s who presented with re...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JSLRT
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898723/ https://www.ncbi.nlm.nih.gov/pubmed/36575003 http://dx.doi.org/10.3960/jslrt.22030 |
_version_ | 1784882488624021504 |
---|---|
author | Takeoka, Kayo Maekawa, Fumiyo Nakagawa, Miho Kishimori, Chiyuki Fukutsuka, Katsuhiro Hayashida, Masahiko Sumiyoshi, Shinji Ohno, Hitoshi |
author_facet | Takeoka, Kayo Maekawa, Fumiyo Nakagawa, Miho Kishimori, Chiyuki Fukutsuka, Katsuhiro Hayashida, Masahiko Sumiyoshi, Shinji Ohno, Hitoshi |
author_sort | Takeoka, Kayo |
collection | PubMed |
description | We describe two follicular lymphoma (FL) patients with MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit translocations. The first patient (case 1) was a man in his 30s who presented with stage IV disease with leukemic manifestation. The second patient (case 2) was a man in his 60s who presented with relapsed FL, but his disease was in a limited stage. Histopathology of the lymph node biopsies revealed grade 3A FL in both cases. MYC positivity and the Ki-67–labeling index were 60–70 and 20% in case 1 and 30 and 50% in case 2, respectively. G-banding revealed t(8;14;18)(q24;q32;q21) in both cases and fluorescence in situ hybridization using MYC, IGH, and BCL2 break-apart probes confirmed t(8;14;18)(+5′BCL2,−3′MYC;+3′MYC,−5′IGH;+5′IGH,−5′BCL2). In case 2, additional materials of der(8)t(8;14;18) were duplicated and translocated to chromosome Y, and t(3;16)(q27;p13)/BCL6::CIITA was identified. We obtained BCL2-major breakpoint region::IGHJ5::IGHG1 and MYC exon 2::IGHA2 fusion sequences by long-distance polymerase chain reaction in case 1, and proposed that t(8;14;18) was generated by two-step translocations and that BCL2::IGH and MYC::IGH involved the same IGH allele. Both patients responded to the standard chemotherapy for FL. We suggest that the presence of t(8;14;18) in FL does not immediately indicate high-grade transformation and aggressive clinical behavior requiring intensive chemotherapy. |
format | Online Article Text |
id | pubmed-9898723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | JSLRT |
record_format | MEDLINE/PubMed |
spelling | pubmed-98987232023-02-13 MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21) Takeoka, Kayo Maekawa, Fumiyo Nakagawa, Miho Kishimori, Chiyuki Fukutsuka, Katsuhiro Hayashida, Masahiko Sumiyoshi, Shinji Ohno, Hitoshi J Clin Exp Hematop Case Report We describe two follicular lymphoma (FL) patients with MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit translocations. The first patient (case 1) was a man in his 30s who presented with stage IV disease with leukemic manifestation. The second patient (case 2) was a man in his 60s who presented with relapsed FL, but his disease was in a limited stage. Histopathology of the lymph node biopsies revealed grade 3A FL in both cases. MYC positivity and the Ki-67–labeling index were 60–70 and 20% in case 1 and 30 and 50% in case 2, respectively. G-banding revealed t(8;14;18)(q24;q32;q21) in both cases and fluorescence in situ hybridization using MYC, IGH, and BCL2 break-apart probes confirmed t(8;14;18)(+5′BCL2,−3′MYC;+3′MYC,−5′IGH;+5′IGH,−5′BCL2). In case 2, additional materials of der(8)t(8;14;18) were duplicated and translocated to chromosome Y, and t(3;16)(q27;p13)/BCL6::CIITA was identified. We obtained BCL2-major breakpoint region::IGHJ5::IGHG1 and MYC exon 2::IGHA2 fusion sequences by long-distance polymerase chain reaction in case 1, and proposed that t(8;14;18) was generated by two-step translocations and that BCL2::IGH and MYC::IGH involved the same IGH allele. Both patients responded to the standard chemotherapy for FL. We suggest that the presence of t(8;14;18) in FL does not immediately indicate high-grade transformation and aggressive clinical behavior requiring intensive chemotherapy. JSLRT 2022-12-28 /pmc/articles/PMC9898723/ /pubmed/36575003 http://dx.doi.org/10.3960/jslrt.22030 Text en © 2022 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License. |
spellingShingle | Case Report Takeoka, Kayo Maekawa, Fumiyo Nakagawa, Miho Kishimori, Chiyuki Fukutsuka, Katsuhiro Hayashida, Masahiko Sumiyoshi, Shinji Ohno, Hitoshi MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21) |
title | MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21) |
title_full | MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21) |
title_fullStr | MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21) |
title_full_unstemmed | MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21) |
title_short | MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21) |
title_sort | myc/bcl2 double- and myc/bcl2/bcl6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21) |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898723/ https://www.ncbi.nlm.nih.gov/pubmed/36575003 http://dx.doi.org/10.3960/jslrt.22030 |
work_keys_str_mv | AT takeokakayo mycbcl2doubleandmycbcl2bcl6triplehitfollicularlymphomasassociatedwitht81418q24q32q21 AT maekawafumiyo mycbcl2doubleandmycbcl2bcl6triplehitfollicularlymphomasassociatedwitht81418q24q32q21 AT nakagawamiho mycbcl2doubleandmycbcl2bcl6triplehitfollicularlymphomasassociatedwitht81418q24q32q21 AT kishimorichiyuki mycbcl2doubleandmycbcl2bcl6triplehitfollicularlymphomasassociatedwitht81418q24q32q21 AT fukutsukakatsuhiro mycbcl2doubleandmycbcl2bcl6triplehitfollicularlymphomasassociatedwitht81418q24q32q21 AT hayashidamasahiko mycbcl2doubleandmycbcl2bcl6triplehitfollicularlymphomasassociatedwitht81418q24q32q21 AT sumiyoshishinji mycbcl2doubleandmycbcl2bcl6triplehitfollicularlymphomasassociatedwitht81418q24q32q21 AT ohnohitoshi mycbcl2doubleandmycbcl2bcl6triplehitfollicularlymphomasassociatedwitht81418q24q32q21 |