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A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2

The N-terminal half of PHF2 harbors both a plant homeodomain (PHD) and a Jumonji domain. The PHD recognizes both histone H3 trimethylated at lysine 4 and methylated nonhistone proteins including vaccinia-related kinase 1 (VRK1). The Jumonji domain erases the repressive dimethylation mark from histon...

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Detalles Bibliográficos
Autores principales:	Horton, John R., Zhou, Jujun, Chen, Qin, Zhang, Xing, Bedford, Mark T., Cheng, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898751/ https://www.ncbi.nlm.nih.gov/pubmed/36596360 http://dx.doi.org/10.1016/j.jbc.2022.102862

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