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Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice

Obesity and diabetes normally cause mitochondrial dysfunction and hepatic lipid accumulation, while fatty acid synthesis is suppressed and malonyl-CoA is depleted in the liver of severe obese or diabetic animals. Therefore, a negative regulatory mechanism might work for the control of mitochondrial...

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Detalles Bibliográficos
Autores principales:	Yao, Haoya, Wang, Yaoqing, Zhang, Xiao, Li, Ping, Shang, Lin, Chen, Xiaocui, Zeng, Jia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898756/ https://www.ncbi.nlm.nih.gov/pubmed/36586435 http://dx.doi.org/10.1016/j.jbc.2022.102845

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