Dysfunctional Extracellular Matrix Remodeling Supports Perianal Fistulizing Crohn′s Disease by a Mechanoregulated Activation of the Epithelial-to-Mesenchymal Transition

BACKGROUND AND AIMS: Perianal fistula represents one of the most disabling manifestations of Crohn′s disease (CD) due to complete destruction of the affected mucosa, which is replaced by granulation tissue and associated with changes in tissue organization. To date, the molecular mechanisms underlyi...

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Detalles Bibliográficos
Autores principales: Rizzo, Giulia, Rubbino, Federica, Elangovan, Sudharshan, Sammarco, Giusy, Lovisa, Sara, Restelli, Silvia, Pineda Chavez, Samuel Elias, Massimino, Luca, Lamparelli, Luigi, Paulis, Marianna, Maroli, Annalisa, Roda, Giulia, Shalaby, Mohammad, Carvello, Michele, Foppa, Caterina, Drummond, Sheona P., Spaggiari, Paola, Ungaro, Federica, Spinelli, Antonino, Malesci, Alberto, Repici, Alessandro, Day, Anthony J., Armuzzi, Alessandro, Danese, Silvio, Vetrano, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898761/
https://www.ncbi.nlm.nih.gov/pubmed/36521659
http://dx.doi.org/10.1016/j.jcmgh.2022.12.006

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