Native Size-Exclusion Chromatography–Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes

The molecular chaperone heat shock protein 90 (HSP90) works in concert with co-chaperones to stabilize its client proteins, which include multiple drivers of oncogenesis and malignant progression. Pharmacologic inhibitors of HSP90 have been observed to exert a wide range of effects on the proteome,...

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Detalles Bibliográficos
Autores principales: Samant, Rahul S., Batista, Silvia, Larance, Mark, Ozer, Bugra, Milton, Christopher I., Bludau, Isabell, Wu, Estelle, Biggins, Laura, Andrews, Simon, Hervieu, Alexia, Johnston, Harvey E., Al-Lazikhani, Bissan, Lamond, Angus I., Clarke, Paul A., Workman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898794/
https://www.ncbi.nlm.nih.gov/pubmed/36549590
http://dx.doi.org/10.1016/j.mcpro.2022.100485

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