The long isoform of the C. elegans ELT-3 GATA factor can specify endoderm when overexpressed

The C. elegans elt-3 gene encodes a GATA transcription factor that is expressed in the hypodermis and has roles in hypodermal specification and regulation of collagen and stress response genes. The gene encodes short and long isoforms, ELT-3A and ELT-3B respectively, that differ upstream of their DN...

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Detalles Bibliográficos
Autores principales: Broitman-Maduro, Gina, Maduro, Morris F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898813/
https://www.ncbi.nlm.nih.gov/pubmed/36748041
http://dx.doi.org/10.17912/micropub.biology.000748
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author Broitman-Maduro, Gina
Maduro, Morris F.
author_facet Broitman-Maduro, Gina
Maduro, Morris F.
author_sort Broitman-Maduro, Gina
collection PubMed
description The C. elegans elt-3 gene encodes a GATA transcription factor that is expressed in the hypodermis and has roles in hypodermal specification and regulation of collagen and stress response genes. The gene encodes short and long isoforms, ELT-3A and ELT-3B respectively, that differ upstream of their DNA-binding domains. Previous work showed that ELT-3A can specify hypodermal cell fates when forcibly overexpressed throughout early embryos. We recently showed that the ELT-3B orthologue from the distantly related species C. angaria can specify endodermal fates when forcibly overexpressed in C. elegans. Here, we show that C. elegans ELT-3B can also specify endoderm.
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spelling pubmed-98988132023-02-05 The long isoform of the C. elegans ELT-3 GATA factor can specify endoderm when overexpressed Broitman-Maduro, Gina Maduro, Morris F. MicroPubl Biol New Finding The C. elegans elt-3 gene encodes a GATA transcription factor that is expressed in the hypodermis and has roles in hypodermal specification and regulation of collagen and stress response genes. The gene encodes short and long isoforms, ELT-3A and ELT-3B respectively, that differ upstream of their DNA-binding domains. Previous work showed that ELT-3A can specify hypodermal cell fates when forcibly overexpressed throughout early embryos. We recently showed that the ELT-3B orthologue from the distantly related species C. angaria can specify endodermal fates when forcibly overexpressed in C. elegans. Here, we show that C. elegans ELT-3B can also specify endoderm. Caltech Library 2023-01-21 /pmc/articles/PMC9898813/ /pubmed/36748041 http://dx.doi.org/10.17912/micropub.biology.000748 Text en Copyright: © 2023 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Broitman-Maduro, Gina
Maduro, Morris F.
The long isoform of the C. elegans ELT-3 GATA factor can specify endoderm when overexpressed
title The long isoform of the C. elegans ELT-3 GATA factor can specify endoderm when overexpressed
title_full The long isoform of the C. elegans ELT-3 GATA factor can specify endoderm when overexpressed
title_fullStr The long isoform of the C. elegans ELT-3 GATA factor can specify endoderm when overexpressed
title_full_unstemmed The long isoform of the C. elegans ELT-3 GATA factor can specify endoderm when overexpressed
title_short The long isoform of the C. elegans ELT-3 GATA factor can specify endoderm when overexpressed
title_sort long isoform of the c. elegans elt-3 gata factor can specify endoderm when overexpressed
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898813/
https://www.ncbi.nlm.nih.gov/pubmed/36748041
http://dx.doi.org/10.17912/micropub.biology.000748
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