Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity

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Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pr...

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Autores principales: Letsinger, Ayland C., Ward, James M., Fannin, Rick D., Mahapatra, Debabrata, Bridge, Matthew F., Sills, Robert C., Gerrish, Kevin E., Yakel, Jerrel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898857/
https://www.ncbi.nlm.nih.gov/pubmed/36739463
http://dx.doi.org/10.1038/s41598-023-29118-6
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author Letsinger, Ayland C.
Ward, James M.
Fannin, Rick D.
Mahapatra, Debabrata
Bridge, Matthew F.
Sills, Robert C.
Gerrish, Kevin E.
Yakel, Jerrel L.
author_facet Letsinger, Ayland C.
Ward, James M.
Fannin, Rick D.
Mahapatra, Debabrata
Bridge, Matthew F.
Sills, Robert C.
Gerrish, Kevin E.
Yakel, Jerrel L.
author_sort Letsinger, Ayland C.
collection PubMed
description Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.
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spelling pubmed-98988572023-02-06 Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity Letsinger, Ayland C. Ward, James M. Fannin, Rick D. Mahapatra, Debabrata Bridge, Matthew F. Sills, Robert C. Gerrish, Kevin E. Yakel, Jerrel L. Sci Rep Article Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2. Nature Publishing Group UK 2023-02-04 /pmc/articles/PMC9898857/ /pubmed/36739463 http://dx.doi.org/10.1038/s41598-023-29118-6 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Letsinger, Ayland C.
Ward, James M.
Fannin, Rick D.
Mahapatra, Debabrata
Bridge, Matthew F.
Sills, Robert C.
Gerrish, Kevin E.
Yakel, Jerrel L.
Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_full Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_fullStr Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_full_unstemmed Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_short Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
title_sort nicotine exposure decreases likelihood of sars-cov-2 rna expression and neuropathology in the hace2 mouse brain but not moribundity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898857/
https://www.ncbi.nlm.nih.gov/pubmed/36739463
http://dx.doi.org/10.1038/s41598-023-29118-6
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