In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range

Area under the curve (AUC)-based vancomycin dosing reduces nephrotoxicity but is burdensome. Reviewing 115 adults receiving ≥2 weeks of outpatient vancomycin, we found AUC-based and trough-based dose adjustments discordant only for troughs <12 or >16 mg/L. Selective versus universal outpatient...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Yufei, Alexander, Bryan T, Avedissian, Sean, Bergman, Scott J, Cortés-Penfield, Nicolás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898881/
https://www.ncbi.nlm.nih.gov/pubmed/36751644
http://dx.doi.org/10.1093/ofid/ofac696
_version_ 1784882525803380736
author Shi, Yufei
Alexander, Bryan T
Avedissian, Sean
Bergman, Scott J
Cortés-Penfield, Nicolás
author_facet Shi, Yufei
Alexander, Bryan T
Avedissian, Sean
Bergman, Scott J
Cortés-Penfield, Nicolás
author_sort Shi, Yufei
collection PubMed
description Area under the curve (AUC)-based vancomycin dosing reduces nephrotoxicity but is burdensome. Reviewing 115 adults receiving ≥2 weeks of outpatient vancomycin, we found AUC-based and trough-based dose adjustments discordant only for troughs <12 or >16 mg/L. Selective versus universal outpatient AUC calculation would likely offer similar benefit with reduced workload.
format Online
Article
Text
id pubmed-9898881
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-98988812023-02-06 In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range Shi, Yufei Alexander, Bryan T Avedissian, Sean Bergman, Scott J Cortés-Penfield, Nicolás Open Forum Infect Dis Brief Report Area under the curve (AUC)-based vancomycin dosing reduces nephrotoxicity but is burdensome. Reviewing 115 adults receiving ≥2 weeks of outpatient vancomycin, we found AUC-based and trough-based dose adjustments discordant only for troughs <12 or >16 mg/L. Selective versus universal outpatient AUC calculation would likely offer similar benefit with reduced workload. Oxford University Press 2023-01-07 /pmc/articles/PMC9898881/ /pubmed/36751644 http://dx.doi.org/10.1093/ofid/ofac696 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Shi, Yufei
Alexander, Bryan T
Avedissian, Sean
Bergman, Scott J
Cortés-Penfield, Nicolás
In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range
title In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range
title_full In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range
title_fullStr In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range
title_full_unstemmed In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range
title_short In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range
title_sort in outpatients receiving parenteral vancomycin, dosing adjustments produced by area under the curve-based and trough-based monitoring differ only at the extremes of the therapeutic trough range
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898881/
https://www.ncbi.nlm.nih.gov/pubmed/36751644
http://dx.doi.org/10.1093/ofid/ofac696
work_keys_str_mv AT shiyufei inoutpatientsreceivingparenteralvancomycindosingadjustmentsproducedbyareaunderthecurvebasedandtroughbasedmonitoringdifferonlyattheextremesofthetherapeutictroughrange
AT alexanderbryant inoutpatientsreceivingparenteralvancomycindosingadjustmentsproducedbyareaunderthecurvebasedandtroughbasedmonitoringdifferonlyattheextremesofthetherapeutictroughrange
AT avedissiansean inoutpatientsreceivingparenteralvancomycindosingadjustmentsproducedbyareaunderthecurvebasedandtroughbasedmonitoringdifferonlyattheextremesofthetherapeutictroughrange
AT bergmanscottj inoutpatientsreceivingparenteralvancomycindosingadjustmentsproducedbyareaunderthecurvebasedandtroughbasedmonitoringdifferonlyattheextremesofthetherapeutictroughrange
AT cortespenfieldnicolas inoutpatientsreceivingparenteralvancomycindosingadjustmentsproducedbyareaunderthecurvebasedandtroughbasedmonitoringdifferonlyattheextremesofthetherapeutictroughrange

Ejemplares similares