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Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer

BACKGROUND: To explore the dosimetric difference between IMRT-VB plan based on the establishment of external expansion structure and virtual bolus (VB) and IMRT-SF based on the skin flash (SF) tool of the Eclipse treatment planning system in postoperative chest wall target intensity modulation radio...

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Autores principales: Tang, Ran, Li, Aimin, Li, Yingjing, Deng, Guanhua, Wang, Yufeng, Xiao, Qing, Zhang, Luosheng, Luo, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898932/
https://www.ncbi.nlm.nih.gov/pubmed/36737788
http://dx.doi.org/10.1186/s13014-023-02217-4
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author Tang, Ran
Li, Aimin
Li, Yingjing
Deng, Guanhua
Wang, Yufeng
Xiao, Qing
Zhang, Luosheng
Luo, Yue
author_facet Tang, Ran
Li, Aimin
Li, Yingjing
Deng, Guanhua
Wang, Yufeng
Xiao, Qing
Zhang, Luosheng
Luo, Yue
author_sort Tang, Ran
collection PubMed
description BACKGROUND: To explore the dosimetric difference between IMRT-VB plan based on the establishment of external expansion structure and virtual bolus (VB) and IMRT-SF based on the skin flash (SF) tool of the Eclipse treatment planning system in postoperative chest wall target intensity modulation radiotherapy plan of breast cancer. METHODS: Twenty patients with breast cancer were randomly selected as subjects to develop IMRT-VB plan based on virtual bolus and IMRT-SF plan based on skin flash tool of Eclipse treatment planning system. The planning target volume, monitor unit (MU) of every single treatment and the dosimetric parameters of organ at risk (OARs) were recorded. Paired t-test was used for normal distribution data while nonparametric paired Wilcoxon rank sum test was used for non-normal distribution data. RESULTS: Both IMRT-VB and IMRT-SF plan can expand outward to the chest wall skin and meet the dose requirements of clinical prescription. The conformal index, the homogeneity index, D(2%), D(98%) and D(50%) were significantly better in IMRT-SF plan than those in IMRT-VB plan (P < 0.05). The average MU of the IMRT-SF plan was much higher than that of the IMRT-VB plan (866.0 ± 68.1 MU vs. 760.9 ± 50.4 MU, P < 0.05). In terms of organ at risk protection, IMRT-SF plan had more advantages in the protection of ipsilateral lung and spinal cord than IMRT-VB plan (P < 0.05). CONCLUSION: Our study indicated that IMRT-SF plan displayed clinical application superiority compared to IMRT-VB plan, and the operation steps of which are simpler and faster. Besides, IMRT-SF plan took advantages in achieve effective external expansion of skin dose intensity and OARs protection.
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spelling pubmed-98989322023-02-05 Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer Tang, Ran Li, Aimin Li, Yingjing Deng, Guanhua Wang, Yufeng Xiao, Qing Zhang, Luosheng Luo, Yue Radiat Oncol Research BACKGROUND: To explore the dosimetric difference between IMRT-VB plan based on the establishment of external expansion structure and virtual bolus (VB) and IMRT-SF based on the skin flash (SF) tool of the Eclipse treatment planning system in postoperative chest wall target intensity modulation radiotherapy plan of breast cancer. METHODS: Twenty patients with breast cancer were randomly selected as subjects to develop IMRT-VB plan based on virtual bolus and IMRT-SF plan based on skin flash tool of Eclipse treatment planning system. The planning target volume, monitor unit (MU) of every single treatment and the dosimetric parameters of organ at risk (OARs) were recorded. Paired t-test was used for normal distribution data while nonparametric paired Wilcoxon rank sum test was used for non-normal distribution data. RESULTS: Both IMRT-VB and IMRT-SF plan can expand outward to the chest wall skin and meet the dose requirements of clinical prescription. The conformal index, the homogeneity index, D(2%), D(98%) and D(50%) were significantly better in IMRT-SF plan than those in IMRT-VB plan (P < 0.05). The average MU of the IMRT-SF plan was much higher than that of the IMRT-VB plan (866.0 ± 68.1 MU vs. 760.9 ± 50.4 MU, P < 0.05). In terms of organ at risk protection, IMRT-SF plan had more advantages in the protection of ipsilateral lung and spinal cord than IMRT-VB plan (P < 0.05). CONCLUSION: Our study indicated that IMRT-SF plan displayed clinical application superiority compared to IMRT-VB plan, and the operation steps of which are simpler and faster. Besides, IMRT-SF plan took advantages in achieve effective external expansion of skin dose intensity and OARs protection. BioMed Central 2023-02-04 /pmc/articles/PMC9898932/ /pubmed/36737788 http://dx.doi.org/10.1186/s13014-023-02217-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Tang, Ran
Li, Aimin
Li, Yingjing
Deng, Guanhua
Wang, Yufeng
Xiao, Qing
Zhang, Luosheng
Luo, Yue
Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer
title Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer
title_full Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer
title_fullStr Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer
title_full_unstemmed Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer
title_short Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer
title_sort dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898932/
https://www.ncbi.nlm.nih.gov/pubmed/36737788
http://dx.doi.org/10.1186/s13014-023-02217-4
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