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The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity cau...

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Autores principales: Zhu, Lujian, Luo, Shengnan, Zhu, Yin, Tang, Shiyue, Li, Chenge, Jin, Xiaozhi, Wu, Faling, Jiang, Huimian, Wu, Lina, Xu, Yejin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899014/
https://www.ncbi.nlm.nih.gov/pubmed/36748023
http://dx.doi.org/10.2147/JIR.S385977
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author Zhu, Lujian
Luo, Shengnan
Zhu, Yin
Tang, Shiyue
Li, Chenge
Jin, Xiaozhi
Wu, Faling
Jiang, Huimian
Wu, Lina
Xu, Yejin
author_facet Zhu, Lujian
Luo, Shengnan
Zhu, Yin
Tang, Shiyue
Li, Chenge
Jin, Xiaozhi
Wu, Faling
Jiang, Huimian
Wu, Lina
Xu, Yejin
author_sort Zhu, Lujian
collection PubMed
description Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy.
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spelling pubmed-98990142023-02-05 The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge Zhu, Lujian Luo, Shengnan Zhu, Yin Tang, Shiyue Li, Chenge Jin, Xiaozhi Wu, Faling Jiang, Huimian Wu, Lina Xu, Yejin J Inflamm Res Review Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy. Dove 2023-01-31 /pmc/articles/PMC9899014/ /pubmed/36748023 http://dx.doi.org/10.2147/JIR.S385977 Text en © 2023 Zhu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhu, Lujian
Luo, Shengnan
Zhu, Yin
Tang, Shiyue
Li, Chenge
Jin, Xiaozhi
Wu, Faling
Jiang, Huimian
Wu, Lina
Xu, Yejin
The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
title The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
title_full The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
title_fullStr The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
title_full_unstemmed The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
title_short The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
title_sort emerging role of ferroptosis in various chronic liver diseases: opportunity or challenge
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899014/
https://www.ncbi.nlm.nih.gov/pubmed/36748023
http://dx.doi.org/10.2147/JIR.S385977
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