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The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity cau...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899014/ https://www.ncbi.nlm.nih.gov/pubmed/36748023 http://dx.doi.org/10.2147/JIR.S385977 |
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author | Zhu, Lujian Luo, Shengnan Zhu, Yin Tang, Shiyue Li, Chenge Jin, Xiaozhi Wu, Faling Jiang, Huimian Wu, Lina Xu, Yejin |
author_facet | Zhu, Lujian Luo, Shengnan Zhu, Yin Tang, Shiyue Li, Chenge Jin, Xiaozhi Wu, Faling Jiang, Huimian Wu, Lina Xu, Yejin |
author_sort | Zhu, Lujian |
collection | PubMed |
description | Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy. |
format | Online Article Text |
id | pubmed-9899014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-98990142023-02-05 The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge Zhu, Lujian Luo, Shengnan Zhu, Yin Tang, Shiyue Li, Chenge Jin, Xiaozhi Wu, Faling Jiang, Huimian Wu, Lina Xu, Yejin J Inflamm Res Review Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy. Dove 2023-01-31 /pmc/articles/PMC9899014/ /pubmed/36748023 http://dx.doi.org/10.2147/JIR.S385977 Text en © 2023 Zhu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Zhu, Lujian Luo, Shengnan Zhu, Yin Tang, Shiyue Li, Chenge Jin, Xiaozhi Wu, Faling Jiang, Huimian Wu, Lina Xu, Yejin The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge |
title | The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge |
title_full | The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge |
title_fullStr | The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge |
title_full_unstemmed | The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge |
title_short | The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge |
title_sort | emerging role of ferroptosis in various chronic liver diseases: opportunity or challenge |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899014/ https://www.ncbi.nlm.nih.gov/pubmed/36748023 http://dx.doi.org/10.2147/JIR.S385977 |
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