Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation

A clinical strain of Klebsiella pneumoniae typed as sequence type 307 carrying three different alleles of the flu gene encoding the Escherichia coli virulence factor antigen 43 associated with biofilm formation was detected and characterized. The flu alleles are located in the chromosome inside puta...

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Autores principales: Tambassi, Martina, Passarini, Elena, Menozzi, Ilaria, Berni, Melissa, Bracchi, Chiara, Dodi, Alessandra, Bolzoni, Luca, Scaltriti, Erika, Morganti, Marina, Ferrarini, Giulia, Sordi, Laura, Sarti, Mario, Ambretti, Simone, Pongolini, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899198/
https://www.ncbi.nlm.nih.gov/pubmed/36695920
http://dx.doi.org/10.1007/s10096-023-04552-6
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author Tambassi, Martina
Passarini, Elena
Menozzi, Ilaria
Berni, Melissa
Bracchi, Chiara
Dodi, Alessandra
Bolzoni, Luca
Scaltriti, Erika
Morganti, Marina
Ferrarini, Giulia
Sordi, Laura
Sarti, Mario
Ambretti, Simone
Pongolini, Stefano
author_facet Tambassi, Martina
Passarini, Elena
Menozzi, Ilaria
Berni, Melissa
Bracchi, Chiara
Dodi, Alessandra
Bolzoni, Luca
Scaltriti, Erika
Morganti, Marina
Ferrarini, Giulia
Sordi, Laura
Sarti, Mario
Ambretti, Simone
Pongolini, Stefano
author_sort Tambassi, Martina
collection PubMed
description A clinical strain of Klebsiella pneumoniae typed as sequence type 307 carrying three different alleles of the flu gene encoding the Escherichia coli virulence factor antigen 43 associated with biofilm formation was detected and characterized. The flu alleles are located in the chromosome inside putative integrative conjugative elements. The strain displays the phenotypes associated with Ag43, i.e. bi-phasic colony morphology and enhanced biofilm production. Furthermore, the strain produces low amount of capsule known to affect Ag43 function. Analysis of 1431 worldwide deposited genomes revealed that 3.7% Klebsiella pneumoniae carry one or two flu alleles. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-023-04552-6.
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spelling pubmed-98991982023-02-06 Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation Tambassi, Martina Passarini, Elena Menozzi, Ilaria Berni, Melissa Bracchi, Chiara Dodi, Alessandra Bolzoni, Luca Scaltriti, Erika Morganti, Marina Ferrarini, Giulia Sordi, Laura Sarti, Mario Ambretti, Simone Pongolini, Stefano Eur J Clin Microbiol Infect Dis Brief Report A clinical strain of Klebsiella pneumoniae typed as sequence type 307 carrying three different alleles of the flu gene encoding the Escherichia coli virulence factor antigen 43 associated with biofilm formation was detected and characterized. The flu alleles are located in the chromosome inside putative integrative conjugative elements. The strain displays the phenotypes associated with Ag43, i.e. bi-phasic colony morphology and enhanced biofilm production. Furthermore, the strain produces low amount of capsule known to affect Ag43 function. Analysis of 1431 worldwide deposited genomes revealed that 3.7% Klebsiella pneumoniae carry one or two flu alleles. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-023-04552-6. Springer Berlin Heidelberg 2023-01-25 2023 /pmc/articles/PMC9899198/ /pubmed/36695920 http://dx.doi.org/10.1007/s10096-023-04552-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Tambassi, Martina
Passarini, Elena
Menozzi, Ilaria
Berni, Melissa
Bracchi, Chiara
Dodi, Alessandra
Bolzoni, Luca
Scaltriti, Erika
Morganti, Marina
Ferrarini, Giulia
Sordi, Laura
Sarti, Mario
Ambretti, Simone
Pongolini, Stefano
Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation
title Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation
title_full Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation
title_fullStr Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation
title_full_unstemmed Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation
title_short Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation
title_sort klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of escherichia coli associated with biofilm formation
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899198/
https://www.ncbi.nlm.nih.gov/pubmed/36695920
http://dx.doi.org/10.1007/s10096-023-04552-6
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