Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition

Modular polyketide synthase (PKS) is an ingenious core machine that catalyzes abundant polyketides in nature. Exploring interactions among modules in PKS is very important for understanding the overall biosynthetic process and for engineering PKS assembly-lines. Here, we show that intermodular recog...

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Detalles Bibliográficos
Autores principales: Zhai, Guifa, Zhu, Yan, Sun, Guo, Zhou, Fan, Sun, Yangning, Hong, Zhou, Dong, Chuan, Leadlay, Peter F., Hong, Kui, Deng, Zixin, Zhou, Fuling, Sun, Yuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899208/
https://www.ncbi.nlm.nih.gov/pubmed/36739290
http://dx.doi.org/10.1038/s41467-023-36213-9

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