Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK–SIRT(1)–PGC(1a) energy metabolism pathway

A large number of data suggest that caloric restriction (CR) has a protective effect on myocardial ischemia/reperfusion injury (I/R) in the elderly. However, the mechanism is still unclear. In this study, we created the I/R model in vivo by ligating the mice left coronary artery for 45 min followed...

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Detalles Bibliográficos
Autores principales: Guo, Zhijia, Wang, Meng, Ying, Xiaodong, Yuan, Jiyu, Wang, Chenggang, Zhang, Wenjie, Tian, Shouyuan, Yan, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899227/
https://www.ncbi.nlm.nih.gov/pubmed/36739302
http://dx.doi.org/10.1038/s41598-023-27611-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899227/
https://www.ncbi.nlm.nih.gov/pubmed/36739302
http://dx.doi.org/10.1038/s41598-023-27611-6

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