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Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK–SIRT(1)–PGC(1a) energy metabolism pathway
A large number of data suggest that caloric restriction (CR) has a protective effect on myocardial ischemia/reperfusion injury (I/R) in the elderly. However, the mechanism is still unclear. In this study, we created the I/R model in vivo by ligating the mice left coronary artery for 45 min followed...
Autores principales: | Guo, Zhijia, Wang, Meng, Ying, Xiaodong, Yuan, Jiyu, Wang, Chenggang, Zhang, Wenjie, Tian, Shouyuan, Yan, Xiaoyan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899227/ https://www.ncbi.nlm.nih.gov/pubmed/36739302 http://dx.doi.org/10.1038/s41598-023-27611-6 |
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