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Circulating microvesicles correlate with radiation proctitis complication after radiotherapy

In a large retrospective study, we assessed the putative use of circulating microvesicles (MVs), as innovative biomarkers of radiation toxicity in a cohort of 208 patients with prostate adenocarcinoma overexposed to radiation. The level of platelet (P)-, monocyte (M)- and endothelial (E)-derived MVs...

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Autores principales: Ribault, Alexandre, Benadjaoud, Mohamed Amine, Squiban, Claire, Arnaud, Laurent, Judicone, Coralie, Leroyer, Aurélie S., Rousseau, Alexandra, Huet, Christelle, Guha, Chandan, Benderitter, Marc, Lacroix, Romaric, Flamant, Stephane, Chen, Emily I., Simon, Jean-Marc, Tamarat, Radia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899237/
https://www.ncbi.nlm.nih.gov/pubmed/36739457
http://dx.doi.org/10.1038/s41598-022-21726-y
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author Ribault, Alexandre
Benadjaoud, Mohamed Amine
Squiban, Claire
Arnaud, Laurent
Judicone, Coralie
Leroyer, Aurélie S.
Rousseau, Alexandra
Huet, Christelle
Guha, Chandan
Benderitter, Marc
Lacroix, Romaric
Flamant, Stephane
Chen, Emily I.
Simon, Jean-Marc
Tamarat, Radia
author_facet Ribault, Alexandre
Benadjaoud, Mohamed Amine
Squiban, Claire
Arnaud, Laurent
Judicone, Coralie
Leroyer, Aurélie S.
Rousseau, Alexandra
Huet, Christelle
Guha, Chandan
Benderitter, Marc
Lacroix, Romaric
Flamant, Stephane
Chen, Emily I.
Simon, Jean-Marc
Tamarat, Radia
author_sort Ribault, Alexandre
collection PubMed
description In a large retrospective study, we assessed the putative use of circulating microvesicles (MVs), as innovative biomarkers of radiation toxicity in a cohort of 208 patients with prostate adenocarcinoma overexposed to radiation. The level of platelet (P)-, monocyte (M)- and endothelial (E)-derived MVs were assessed by flow cytometry. Rectal bleeding toxicity scores were collected at the time of blood sampling and during the routine follow-up and were tested for association with MVs using a multivariate logistic regression. MVs dosimetric correlation was investigated using dose volume histograms information available for a subset of 36 patients. The number of PMVs was significantly increased in patients with highest toxicity grades compared to lower grades. Risk prediction analysis revealed that increased numbers of PMVs, and an increased amount of MMVs relative to EMVs, were associated with worst rectal bleeding grade compared to the time of blood sampling. Moreover, a significant correlation was found between PMV and MMV numbers, with the range of doses up to the median exposure (40 Gy) of bladder/rectum and anterior rectal wall, respectively. MVs could be considered as new biomarkers to improve the identification of patients with high toxicity grade and may be instrumental for the prognosis of radiation therapy complications.
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spelling pubmed-98992372023-02-06 Circulating microvesicles correlate with radiation proctitis complication after radiotherapy Ribault, Alexandre Benadjaoud, Mohamed Amine Squiban, Claire Arnaud, Laurent Judicone, Coralie Leroyer, Aurélie S. Rousseau, Alexandra Huet, Christelle Guha, Chandan Benderitter, Marc Lacroix, Romaric Flamant, Stephane Chen, Emily I. Simon, Jean-Marc Tamarat, Radia Sci Rep Article In a large retrospective study, we assessed the putative use of circulating microvesicles (MVs), as innovative biomarkers of radiation toxicity in a cohort of 208 patients with prostate adenocarcinoma overexposed to radiation. The level of platelet (P)-, monocyte (M)- and endothelial (E)-derived MVs were assessed by flow cytometry. Rectal bleeding toxicity scores were collected at the time of blood sampling and during the routine follow-up and were tested for association with MVs using a multivariate logistic regression. MVs dosimetric correlation was investigated using dose volume histograms information available for a subset of 36 patients. The number of PMVs was significantly increased in patients with highest toxicity grades compared to lower grades. Risk prediction analysis revealed that increased numbers of PMVs, and an increased amount of MMVs relative to EMVs, were associated with worst rectal bleeding grade compared to the time of blood sampling. Moreover, a significant correlation was found between PMV and MMV numbers, with the range of doses up to the median exposure (40 Gy) of bladder/rectum and anterior rectal wall, respectively. MVs could be considered as new biomarkers to improve the identification of patients with high toxicity grade and may be instrumental for the prognosis of radiation therapy complications. Nature Publishing Group UK 2023-02-04 /pmc/articles/PMC9899237/ /pubmed/36739457 http://dx.doi.org/10.1038/s41598-022-21726-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ribault, Alexandre
Benadjaoud, Mohamed Amine
Squiban, Claire
Arnaud, Laurent
Judicone, Coralie
Leroyer, Aurélie S.
Rousseau, Alexandra
Huet, Christelle
Guha, Chandan
Benderitter, Marc
Lacroix, Romaric
Flamant, Stephane
Chen, Emily I.
Simon, Jean-Marc
Tamarat, Radia
Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
title Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
title_full Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
title_fullStr Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
title_full_unstemmed Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
title_short Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
title_sort circulating microvesicles correlate with radiation proctitis complication after radiotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899237/
https://www.ncbi.nlm.nih.gov/pubmed/36739457
http://dx.doi.org/10.1038/s41598-022-21726-y
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