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A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease

Neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD), but controversies persist. Studies reporting concentrations of blood or cerebrospinal fluid (CSF) markers for patients with PD and controls were included and extracted. Pooled Hedges’g was adopted to illustrate c...

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Autores principales: Qu, Yi, Li, Jiangting, Qin, Qixiong, Wang, Danlei, Zhao, Jingwei, An, Ke, Mao, Zhijuan, Min, Zhe, Xiong, Yongjie, Li, Jingyi, Xue, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899271/
https://www.ncbi.nlm.nih.gov/pubmed/36739284
http://dx.doi.org/10.1038/s41531-023-00449-5
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author Qu, Yi
Li, Jiangting
Qin, Qixiong
Wang, Danlei
Zhao, Jingwei
An, Ke
Mao, Zhijuan
Min, Zhe
Xiong, Yongjie
Li, Jingyi
Xue, Zheng
author_facet Qu, Yi
Li, Jiangting
Qin, Qixiong
Wang, Danlei
Zhao, Jingwei
An, Ke
Mao, Zhijuan
Min, Zhe
Xiong, Yongjie
Li, Jingyi
Xue, Zheng
author_sort Qu, Yi
collection PubMed
description Neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD), but controversies persist. Studies reporting concentrations of blood or cerebrospinal fluid (CSF) markers for patients with PD and controls were included and extracted. Pooled Hedges’g was adopted to illustrate comparisons, and covariates were used to explore sources of heterogeneity. Finally, 152 studies were included. Increased IL-6, TNF-α, IL-1β, STNFR1, CRP, CCL2, CX3CL1, and CXCL12 levels and decreased INF-γ and IL-4 levels were noted in the PD group. In addition, increased CSF levels of IL-6, TNF-α, IL-1β, CRP and CCL2 were revealed in patients with PD compared to controls. Consequently, significantly altered levels of inflammatory markers were verified between PD group and control, suggesting that PD is accompanied by inflammatory responses in both the peripheral blood and CSF. This study was registered with PROSPERO, CRD42022349182.
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spelling pubmed-98992712023-02-06 A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease Qu, Yi Li, Jiangting Qin, Qixiong Wang, Danlei Zhao, Jingwei An, Ke Mao, Zhijuan Min, Zhe Xiong, Yongjie Li, Jingyi Xue, Zheng NPJ Parkinsons Dis Review Article Neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD), but controversies persist. Studies reporting concentrations of blood or cerebrospinal fluid (CSF) markers for patients with PD and controls were included and extracted. Pooled Hedges’g was adopted to illustrate comparisons, and covariates were used to explore sources of heterogeneity. Finally, 152 studies were included. Increased IL-6, TNF-α, IL-1β, STNFR1, CRP, CCL2, CX3CL1, and CXCL12 levels and decreased INF-γ and IL-4 levels were noted in the PD group. In addition, increased CSF levels of IL-6, TNF-α, IL-1β, CRP and CCL2 were revealed in patients with PD compared to controls. Consequently, significantly altered levels of inflammatory markers were verified between PD group and control, suggesting that PD is accompanied by inflammatory responses in both the peripheral blood and CSF. This study was registered with PROSPERO, CRD42022349182. Nature Publishing Group UK 2023-02-04 /pmc/articles/PMC9899271/ /pubmed/36739284 http://dx.doi.org/10.1038/s41531-023-00449-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Qu, Yi
Li, Jiangting
Qin, Qixiong
Wang, Danlei
Zhao, Jingwei
An, Ke
Mao, Zhijuan
Min, Zhe
Xiong, Yongjie
Li, Jingyi
Xue, Zheng
A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease
title A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease
title_full A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease
title_fullStr A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease
title_full_unstemmed A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease
title_short A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease
title_sort systematic review and meta-analysis of inflammatory biomarkers in parkinson’s disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899271/
https://www.ncbi.nlm.nih.gov/pubmed/36739284
http://dx.doi.org/10.1038/s41531-023-00449-5
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