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An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration

Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory function. MtFAS generates the octanoic acid precursor for lipoic acid synthesis, but the role of longer fatty acid products has remained unclear. The structurally well-characterized component of mtFAS, human 2E-enoyl-ACP reducta...

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Detalles Bibliográficos
Autores principales:	Tanvir Rahman, M., Kristian Koski, M., Panecka-Hofman, Joanna, Schmitz, Werner, Kastaniotis, Alexander J., Wade, Rebecca C., Wierenga, Rik K., Kalervo Hiltunen, J., Autio, Kaija J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899272/ https://www.ncbi.nlm.nih.gov/pubmed/36739436 http://dx.doi.org/10.1038/s41467-023-36358-7

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